Description, Causes and Risk Factors:

A tumor of the distal dermal segment of a sweat gland.

Acrospiromas are cutaneous tumors of sweat duct differentiation. They usually present as slowly enlarging 1 to 2 cm nodules in middle-aged or older adults without site predilection. Acrospiromas are benign, and treatment consists of surgical excision.

Malignant acrospiroma is an uncommon tumor of the eccrine sweat gland. In contrast to its relatively more common benign counterpart, malignant acrospiroma is highly invasive, often with significant lymphatic and distant metastasis.

The specific causes of acrospiroma are not known. In contrast to some adnexal neoplasms of follicular lineage, acrospiroma development has no established familial predilection.


Researchers report the case of a 66-year-old female with a recurrent malignant acrospiroma. This patient's tumor was removed by wide radical resection, including chest wall excision, followed by reconstructive surgery and radiotherapy. After 16 months there is no evidence of local recurrence or distant metastasis.


Acrospiromatypically are asymptomatic, slow-growing, or stable nodular lesions.Although most are asymptomatic, pain can be a presenting sign.Acrospiromaare one of many types of benign adnexal neoplasms that can manifest secondarily within a nevus sebaceous.


Differential diagnosis:

    Apocrine mixed tumor.

  • Metastatic disease (renal cell carcinoma).

  • Primary skin tumors with follicular differentiation.

  • Sebaceous differentiation or sweat gland differentiation.

  • Glomus tumor (different staining pattern).

The establishment of this diagnosis is difficult on both clinical and histopathologic grounds. After diagnosis, wide surgical excision is warranted to completely extirpate these lesions. On histologic examination they are multilobular dermal masses composed of a biphasic cell population. The diagnosis can be fully established after surgical excision with subsequent microscopical examination by an appropriately trained and certified dermatopathologist.

Imaging studies are not needed in the evaluation of this benign and typically superficial adnexal neoplasm.In a dermoscopy evaluation, researchers suggested acrospiromacan mimic amelanotic melanoma.


The primary treatment is wide local excision with or without lymph node dissection. The efficacy of adjuvant chemotherapy and radiation therapy requires further investigation. Researchers describe a case of malignant eccrine acrospiroma in an 80-year-old man, and we review the literature on this tumor, with emphasis on the differential diagnosis.

NOTE: The above information is educational purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.

DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.


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