ACTH secreting tumor

ACTH secreting tumor: Description, Causes, and Risk Factors:

ACTHACTH - the pituitary gland or "master gland" is extremely important in regulating the function of many other glands and organs of the body. It lies behind and between the eyes at the base of the brain, just beneath the hypothalamus to which it is connected by a thin stalk.

Adrenocorticotropic hormone (ACTH): A polypeptide hormone, consisting of 39 amino acids, which is synthesized from proopiomelanocortin (POMC) and secreted from corticotropes in the anterior lobe of the pituitary gland in response to the hormone corticotropin-releasing hormone (CRH) released by the hypothalamus. Adrenocorticotropic hormone is secreted in short bursts every few hours and is increased by stress. In turn, it controls secretion of corticosteroids, including cortisol, aldosterone, and androgens, by the adrenal glands. Most important of these is its stimulation of cortisol production.

ACTH production is partly controlled by the hypothalamus and partly by the level of cortisol in the blood. When ACTH levels are high, the production of cortisol is increased; this, in turn, suppresses the release of this from the pituitary. If ACTH levels are low, cortisol production falls and the hypothalamus releases factors that stimulate the pituitary to increase ACTH production.

These pituitary glands secretes hormone called adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to make proteins called glucocorticoids. When the body makes too much ACTH, it causes a disorder such as ACTH-secreting tumor. Most patients who develop this disorder are women in their 30s and 40s. This tumors account for 10 to 15 percent of pituitary tumors.

Most ectopic adrenocorticotropic hormone ACTH-secreting tumors are bronchial carcinoids and many are malignant.

Symptoms of ACTH-secreting tumor:

Symptoms Include:


Localization of ectopic ACTH-secreting tumors can be extremely difficult and continues to be a challenge for endocrinologists. The majority of these tumors are of neuroendocrine origin and consequently may show high expression of somatostatin receptors.

This disease is diagnosed using blood tests that look for abnormal secretion of a hormone called cortisol. MRI may also be employed, but sometimes a pituitary tumor that causes this tumor is so small that it may not be visible using this imaging test.If the tumor cannot be seen on MRI or if the diagnosis is uncertain, a test called petrosal venous sampling may be necessary. This is a procedure during which a sample of blood is taken from the petrosal sinuses -which drain the pituitary gland on both sides -- and checked for elevated cortisol levels. The test can also help locate the tumor within the pituitary gland if the cortisol level is found to be higher on one side compared to the other.


Surgery to remove the tumor is the primary therapy ACTH-secreting tumor. The surgery is often performed through a minimally invasive approach called transsphenoidal transnasal resection, whereby the surgeon removes the tumor through an incision in the nasal passage. In cases where the tumor is too large to be removed through this approach, the surgeon performs a craniotomy, removing the tumor through an incision in the front of the skull.

Disclaimer: The following tests, drugs and medications, surgical procedures are in some way related to, or used in the treatment. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.

DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.


Submit a Comment

Your email address will not be published. Required fields are marked *

Cart Preview

Cheap Drugs May Help Prevent Dementia after a Stroke

Cheap Drugs May Help Prevent Dementia after a Stroke

A new research from the University of Edinburgh, UK, suggests that cheap cilostazol tablets may reduce damage to arteries, which lead to blood clots, resulting in strokes and cognitive decline. The researchers plan to assess the medications’ ability to cut the risk of...

Flavonoids in Fruits and Vegetables May Preserve Lung Function

Flavonoids in Fruits and Vegetables May Preserve Lung Function

A new study from the US discovers that flavonoids, natural compounds found in fruits and vegetables, may help preserve the lung function, which tends to decline with age. For the study, a team of researchers looked at data from 463 adults from Norway and England whose...

Quiz about this article

Please answer on few questions to make our service more useful

Featured Products

Spring is Here: Top 6 Outdoor Sports

Good weather is the best reason to do outdoor sports, which will help not only lose weight, but also will strengthen health. Bicycle The sun dries out the local paths, so you can safely sit on your favorite bike and confidently twist the pedals, where the eyes look....

read more

First Aid in Case of Injuries for Sport and Exercise

First aid for injuries consists of simple rules that need to be clearly implemented. If this is a closed injury, you need to immobilize the injured limb, otherwise the person may lose consciousness from a painful shock. If you need to get to the emergency room...

read more