Caffeine-containing drugs

Caffeine-containing drugs

Caffeine-containing drugs is a psychoactive substance that stimulates the central nervous system. The chemical formula of caffeine is C8H10NO2. A substance chemically is similar to adenosine, an agent that makes a person feel tired.

Caffeine is commonly used as an analgetic to relieve headache or migraine, it may be used as a supplement to lose weight or central nervous system stimulator. Caffeine-containing drugs formulations may be both over-the-counter or prescription medicines. The combinations of caffeine with other ingredients provide better treatment effects.

Caffeine-containing drugs



Contraindications to Caffeine-containing drugs medicines include allergy to caffeine and the age under 12. It is not recommended to use caffeine to reduce sleepiness or substitute the proper sleep.



Caffeine tolerance test

Caffeine tolerance test

Caffeine-containing drugs should be avoided by pregnant women as long as high doses of caffeine may be associated with miscarriage and poor fetal growth.

Infants may experience excessive wakefulness and hyperactivity.

If сaffeine-containing drugs is used in children younger than 12 the child’s condition should be monitored precisely to avoid delirium and behaviour/mood changes.


Side effects

Common side effects of Caffeine-containing drugs include the following:

  • difficulty sleeping/insomnia;
  • nervousness or anxiety, irritability;
  • nausea, diarrhea and vomiting;
  • headache;
  • serious allergic reactions;
  • tachycardia (rapid heart rate) or palpitations;
  • increased blood pressure;
  • chest pain;


Caffeine-containing drugs: storage

Caffeine drugs should be kept at room temperature (between 15-30 degrees C) away from heat, moisture and light. It is recommended to store the medicines in a closed container.

Caffeine (or Caffeine pills)

Caffeine citrate may be found in the drug stores under the following brand names: NoDoz, Vivarin, Revive, Stay Awake, Enerjets, Lucidex.


Caffeine citrate

Caffeine citrate is administered as a treatment for apnea (absence of breathing or other breathing problems) in newborns who were born prematurely. Caffeine citrate may be used orally (as caffeine citrate oral solution) or by a slow intravenous injection.

Loading dose of caffeine citrate intravenously is 20 mg/kg or 10-20 mg/kg orally in a single dose. Maintenance therapy requires dose at 5 mg/kg intravenously or orally.


Caffeine and Sodium  Benzoate Injection
The medicine is typically used to stimulate the breathing center in newborns who don’t breathe. However, this drug may also be prescribed to boost energy and alleviate drowsiness.

Caffeine and sodium benzoate is administered as a slow intravenous injection.

The maximum dose of this medicine is 500 mg, the dose should be counted based on the weight of the person – 8 mg/kg (4 mg/kg in terms of anhydrous caffeine), the drug may be injected up to every 4 hours.


CCP Caffeine Free

1 tablet of CCP Caffeine Free contains 325 mg of Acetaminophen (analgetic which relieves pain and reduces fever), 200 mg of Guaifenesin (expectorant which thins the mucus) and 5 mg of Phenylephrine HCl (decongestant which helps relieve the congestion of the nose or ear). The medicine is used for the treatment of colds and flu.

2 tablets are taken every 4 hours. The tablet should be swallowed without chewing or dissolving.

It is crucial to avoid this medicine if a person is already receiving any other drug containing acetaminophen or monoamine oxidase inhibitor (MAOI).

Related: Finnish Researchers Created a Unique Coffee that Treats Depression


Formulations containing caffeine and ergotamine (Cafatine, Cafergot, Ercaf) are administered for the treatment and prevention of vascular headaches (migraine and cluster headache, “histaminic cephalalgia”) orally (as tablets) or rectally (as suppository).

The pain is usually relieved in about 30 minutes after the medicine was used.

The maximum dose is 10 tablets/5 suppositories in 7 days.

This combination should not be administered if a person is taking antifungals such as itraconazole and ketoconazole (Nizoral); clarithromycin; erythromycin (E-Mycin, Erythrocin); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir); or troleandomycin (TAO).

Nausea and vomiting are the common side effects of ergotamine.


Magnesium Salicylate-Caffeine Tablet

Magnesium Salicylate-Caffeine is used to relieve pain during menstruation, headache or mild pain associated with arthritis.