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Caffeine tolerance

caffeine toleranceCaffeine tolerance is a condition when caffeine has no more effect on the person’s body.


Caffeine is the most consumed psychoactive substance and therefore a drug.  It was estimated that about 80% of the world’s population consume caffeine every day. The popularity of this substance is connected with its ability to alleviate fatigue, increase the feeling of wakefulness and improve concentration and focusing.

However, it was estimated that 5 grams of caffeine (30-40 cups of regular coffee) may result in the death of the consumer.

The caffeine

The chemical formula of caffeine is C8H10NO2. A substance chemically is similar to adenosine, an agent that makes a person feel tired. In the body, this compound slows down nerve activity and therefore promotes sleep. Adenosine influences on the blood and oxygen supply to the brain by dilatation of the vessels. The level of adenosine in the body increases gradually during the day and it is suggested that this substance is responsible for the need to sleep.

Caffeine binds to the adenosine receptors in the brain and this way stimulates the central nervous system.  At the same time caffeine influences on a hormonal balance causing the growth of adrenaline level and the alertness increases Another effect – feeling of arousal – is connected with the increasing level of dopamine in the brain after the consumption of caffeine.
Caffeine can be synthesized from uric acid, although it occurs naturally in the leaves, seeds, or fruit of more than 60 plant species, including:

  • Coffee beans ;
  • Tea leaves;
  • Kola nuts;
  • Cacao beans ;
  • Guarana;
  • Yerba mate;
  • Yoco;

Caffeine may be found in coffee, tea and chocolate, but it is also added to gum, jelly beans, waffles, water, syrup, and more. Caffeine may be even be added to marshmallows, sunflower seeds, and other snacks for its stimulant effect.

The amount of caffeine included in some common foods and beverages are:

  • Coffee, brewed – 102 -200 milligrams per cup;
  • Coffee, instant – 27-173 milligrams per cup;
  • Coffee, decaffeinated – 3-12 milligrams per cup;
  • Tea, instant – 28 milligrams per cup;
  • Tea, canned iced – 22-36 milligrams per 12 ounces;
  • Caffeine-containing cola and other soft drinks – 36-71 milligrams per 12 ounces;
  • Cocoa – 3 – 13 milligrams per cup;
  • Chocolate, milk – 3-6 milligrams per ounce;
  • Chocolate, bittersweet – 25 milligrams per ounce;
    Read also: Caffeine Might Be Able to Fight Inflammation that Causes Heart Issues
Caffeine tolerance test

Caffeine tolerance test

Risk factors

People who consume a lot of coffee are at risk of developing this condition. The excessive intake of caffeine is also associated with some health problems.


When a person ingests caffeine, he/she artificially reduces sleepiness and increases wakefulness. Over time, the brain will start spouting more adenosine receptors in an effort to  restore the proper functions of adenosine—  so that the person will have to consume more caffeine to keep the sleepiness at bay, and he/she will feel increasingly worse when he/she doesn’t get it. To some extent, at least.


Caffeine tolerance can be reset or prevented.

Caffeine Tolerance Reset: A caffeine detox helps to eliminate caffeine from the body. This process may last from  2 weeks to 2 months, depending on the daily amount of caffeine consumed. Rutaecarpine (herb) provides faster elimination of the substance from the body.

Occasional consumption of the caffeine is the best method to prevent the caffeine tolerance. It is recommended to consume coffee once or twice a week with several days in between the intake.





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