- Varicose veins.
- Tumours (pilomatrixoma, cysts, basal cell carcinomas and others).
- Connective tissue disease (dermatomyositis, systemic sclerosis, cutaneous lupus erythematosus).
- Inherited diseases of connective tissue (Ehlers-Danlos syndrome, Werner syndrome, Pseudoxanthoma elasticum, Rothmund-Thomson syndrome).
- Paraneoplastic hypercalcemia.
- Destructive bone disease, e.g. Paget disease.
- Milk-alkali syndrome.
- Excessive vitamin D intake.
- Chronic renal failure.
- Lesions may become tender and ulcerate, discharging chalk-like creamy material consisting mainly of calcium phosphate with a small amount of calcium carbonate.
- Fingertip lesions may be painful, while lesions at other sites may restrict joint mobility and limit movement due to stiffening of the skin.
- In severe cases cutaneous gangrene may occur.
- Molluscum contagiosum.
- Osteoma Cutis.
- Genital warts.
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