- Genetics, family history.
- Female gender.
- Low-?ber, high-calorie diet.
- Pregnancy and parity.
- Prolonged fasting.
- Oral contraceptives.
- Low-level physical activities.
- Rapid weight loss (> 1.5 kg/wk).
- Hypertriglyceridemia/low high-density lipoprotein.
- Metabolic syndrome.
- Gallbladder stasis.
- Speci?c diseases (cirrhosis, Crohn's disease with severe ileal involvement/resection).
- Nausea and vomiting.
- Severe pain in the upper right abdomen.
- Dark urine.
- Rapid heart beat.
- Abrupt drop in blood pressure.
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