Description, Causes and Risk Factors:
Alternative Name: Interstitial neuritis.
Inflammation of the connective tissue framework of a nerve.
Connective tissue forms a framework upon which epithelial tissue rests and within which nerve tissue and muscle tissue are embedded. Blood vessels and nerves travel through connective tissue.
Connective tissue functions not only as a mechanical support for other tissues but also as an avenue for communication and transport among other tissues. Most significantly, connective tissue is the stage for inflammation. The principal cell types involved in immunological defense are found within connective tissue
The most common connective tissue cells are:
Adipocytes, which store fat.
Mast cells, macrophages, and lymphocytes, cells with immune function which participate in inflammation.
Fibroblasts, which secrete collagen and other elements of the extracellular matrix.
The causes of Eichhorst neuritis are the same as those of fibrositis in general. It may occur as a manifestation of generalized rheumatism, or it may come on without apparent cause. Hypertrophic Eichhorst neuritis is a rate condition characterized by thickening of affected nerves due to hyperplasia of the sheath of Schwann. It may involve peripheral nerves, spinal nerve roots and the cauda equina, singly or in combination.
Physical injuries, emotional trauma, or viral infections such as Epstein-Barr may trigger the disorder, but no one trigger has proven to be a cause of this disorder.
Some have speculated that lower levels of serotonin (A vasoconstrictor, liberated by blood platelets, that inhibits gastric secretion and stimulates smooth muscle; present in relatively high concentrations in some areas of the central nervous system [CNS]) in the blood leads to lowered pain thresholds or an increased sensitivity to pain. The lowered pain thresholds may be caused by the reduced effectiveness of the body's natural endorphin painkillers and the increased presence of a chemical called "substance P." Substance P amplifies pain signals. There have been some studies that link the disease to sudden trauma to the CNS.
Studies have shown that morbidity and mortality rates tend to be very high if the condition is untreated and systemic or if the condition is misdiagnosed.
Eichhorst neuritis is characterized by five chief symptoms radiating pain, tenderness in the vicinity of the nerve trunk, paresthesia or objective sensory loss, muscular wasting or paresis, loss of deep reflexes.
There are no diagnostic investigations or widely accepted pathogenic mechanisms for this disease. Despitedifferent diagnostic criteria, many demographic and clinical similarities including trigger points (TPs). The terms are often misusedinterchangeably. There are few differences in the symptoms, physical findings, laboratory tests, functional status, psychosocial features and psychiatric disorders.
Treatments usually involve trial and error. There is no clear treatment solution. Patients and doctors need to work together to make the best choices for individual symptoms and concerns.
If these methods fail to improve symptoms, an antidepressant or muscle relaxant may be added to the treatment. Doctors usually prescribe these drugs because they may improve pain tolerance.
Patient education and programs that encourage coping skills are an important part of any treatment plan.
Patients may start with physical therapy, exercise, stress reduction techniques, and cognitive behavioral therapy [CBT].
Medications may include: Muscle relaxants, pain relievers, and sleep medications.
Note: Side effects of medications usually present.
NOTE: The above information is educational purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.
DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.
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