Eosinophilic gastroenteritis: Description, Causes and Risk Factors:Abbreviation: EG.Alternative Name: Eosinophilic gastritis.Eosinophilic gastroenteritis is a rare disease of unknown etiology characterized by patchy or diffuse eosinophilic infiltration of the gastrointestinal tract wall with various gastrointestinal manifestations. The disease is rare, and the incidence is difficult to estimate. However, >280 cases have been reported in medical literature.The majority of the cases of Eosinophilic gastroenteritis are reported in whites, with some cases occurring in Asians. A slight male preponderance has been reported. The majority of patients clinically present in the third-to-fifth decades, but the disease can affect any age group.The exact cause of Eosinophilic gastroenteritis is unknown, but parasites, immune disease and allergies to certain food items are all potential causes. The exact pathophysiology of the disease is unknown, but is associated with selective infiltration of eosinophils in parts of GI tract. The disorder is classified into primary or secondary subtypes. The primary subtypes include atopic, non-atopic and familiar variants. This are also called as allergic idiopathic eosinophilic gastritis. Eosinophilic involvement of the gut may be mucosal, muscularis and serosal causing variability in the presentation.Most patients have increased total Immunoglobulin E (IgE) and food specific IgE. In some patients, increased secretion of interleukin 4 (IL4) and interleukin 5 (IL5) from peripheral blood T cells home have been reported.Some foods can trigger the Eosinophilic gastroenteritis they may include milk, soy, wheat, eggs, nuts, shellfish, corn, rice, beef, pork, chicken, turkey.Symptoms:Symptom may include:
Because there is no gold standard for this disease, a wide variety of diagnostic criteria is presented. Definitive diagnosis requires histological evidence ofeosinophilic infiltration. As eosinophilic infiltrates canbe diffused or patchy in distribution, multiple biopsiesshould be done to avoid missing the diagnosis. Inpatients with subserosal disease, abdominal paracentesisdemonstrates a sterile fluid with a high eosinophil count.In cases where the disease is purelymuscular, endoscopic biopsy may be nondiagnostic and may require laparoscopicfull thickness biopsy.Ultrasound and computed tomography scans mayshow thickened intestinal walls and, occasionally, localized lymphadenopathy. However, similar changes canalso be found in other diseases such as Crohn's disease,lymphoma and granulomatous disease.Laboratory Tests May Include:
General History & Examination.
Complete blood count and differential.
Erythrocyte Sedimentation Rate (ESR).
Chemistry (serum bilirubin).
Imaging Studies May Include:
Endoscopy & biopsy of Upper & Lower GI tract
Ascitic fluid analysis.
Treatment of Eosinophilic gastroenteritis:There have been no randomized prospective clinical trials regarding therapy. Thus, the treatment is empirical and based on the severity of the clinical manifestations. Patients with mild disease can be treated symptomatically. More symptomatic patients and those with evidence of malabsorption need more aggressive therapy.Corticosteroid therapy is the mainstay of treatment of Eosinophilic gastroenteritis both in adults as well as in children. The appropriate duration of steroid therapy is unknown. Signs may recur and medication is usually needed for life.A diet change to a hypoallergenic diet has been used with some success. If a diagnosis of Eosinophilic gastroenteritis is made, it is important to maintain your ferret on a strict diet, as treats and dietary changes can lead to a recurrence of clinical signs.NOTE: The above information is educational purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.
A new study from China suggests that estrogen and vitamin D may help postmenopausal women to prevent metabolic syndrome. Within the frame of the study, the researchers included 616 postmenopausal women aged 49–86 years. None of them was taking estrogen or vitamin D...
According to recent research from Karolinska Institutet in Solna, published in the journal Psychological Bulletin, women may remember words and faces a little bit better than men. A team of researchers analyzed 617 studies that were conducted between 1973 and 2013 and...
Many people are motivated for active sports in spring. However, before you buy a membership, you should check which exercises are useful to you and which ones should not be done in any way. Unfortunately, nowadays there are practically no people with an absolutely...
In childhood, many of us dreamed of learning to jump high. Now, after years, it became easier - Kangoo Jumps has appeared. This is one of the relatively new, but quickly gaining popularity types of fitness training. There are several advantages of jumpers. ...
It is time for us to find the solution how to deal with extra weight which is coming with Christmas and New Year’s celebrations because 2018 is almost over and 2019 is getting closer. The main aim is obviously staying in shape and today will find an effective way to...