Eosinophilic gastroenteritis: Description, Causes and Risk Factors:Abbreviation: EG.Alternative Name: Eosinophilic gastritis.Eosinophilic gastroenteritis is a rare disease of unknown etiology characterized by patchy or diffuse eosinophilic infiltration of the gastrointestinal tract wall with various gastrointestinal manifestations. The disease is rare, and the incidence is difficult to estimate. However, >280 cases have been reported in medical literature.The majority of the cases of Eosinophilic gastroenteritis are reported in whites, with some cases occurring in Asians. A slight male preponderance has been reported. The majority of patients clinically present in the third-to-fifth decades, but the disease can affect any age group.The exact cause of Eosinophilic gastroenteritis is unknown, but parasites, immune disease and allergies to certain food items are all potential causes. The exact pathophysiology of the disease is unknown, but is associated with selective infiltration of eosinophils in parts of GI tract. The disorder is classified into primary or secondary subtypes. The primary subtypes include atopic, non-atopic and familiar variants. This are also called as allergic idiopathic eosinophilic gastritis. Eosinophilic involvement of the gut may be mucosal, muscularis and serosal causing variability in the presentation.Most patients have increased total Immunoglobulin E (IgE) and food specific IgE. In some patients, increased secretion of interleukin 4 (IL4) and interleukin 5 (IL5) from peripheral blood T cells home have been reported.Some foods can trigger the Eosinophilic gastroenteritis they may include milk, soy, wheat, eggs, nuts, shellfish, corn, rice, beef, pork, chicken, turkey.Symptoms:Symptom may include:
Because there is no gold standard for this disease, a wide variety of diagnostic criteria is presented. Definitive diagnosis requires histological evidence ofeosinophilic infiltration. As eosinophilic infiltrates canbe diffused or patchy in distribution, multiple biopsiesshould be done to avoid missing the diagnosis. Inpatients with subserosal disease, abdominal paracentesisdemonstrates a sterile fluid with a high eosinophil count.In cases where the disease is purelymuscular, endoscopic biopsy may be nondiagnostic and may require laparoscopicfull thickness biopsy.Ultrasound and computed tomography scans mayshow thickened intestinal walls and, occasionally, localized lymphadenopathy. However, similar changes canalso be found in other diseases such as Crohn's disease,lymphoma and granulomatous disease.Laboratory Tests May Include:
General History & Examination.
Complete blood count and differential.
Erythrocyte Sedimentation Rate (ESR).
Chemistry (serum bilirubin).
Imaging Studies May Include:
Endoscopy & biopsy of Upper & Lower GI tract
Ascitic fluid analysis.
Treatment of Eosinophilic gastroenteritis:There have been no randomized prospective clinical trials regarding therapy. Thus, the treatment is empirical and based on the severity of the clinical manifestations. Patients with mild disease can be treated symptomatically. More symptomatic patients and those with evidence of malabsorption need more aggressive therapy.Corticosteroid therapy is the mainstay of treatment of Eosinophilic gastroenteritis both in adults as well as in children. The appropriate duration of steroid therapy is unknown. Signs may recur and medication is usually needed for life.A diet change to a hypoallergenic diet has been used with some success. If a diagnosis of Eosinophilic gastroenteritis is made, it is important to maintain your ferret on a strict diet, as treats and dietary changes can lead to a recurrence of clinical signs.NOTE: The above information is educational purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.
A new study, published in the Journal of Applied Psychology, finds that a hot bath may help reduce inflammation and improve metabolism. As a part of an experiment, each study participant took a hot bath with water temperature 102°F (39°C) for one hour. The researchers...
New research, executed by scientists from Iowa State University, finds that lifting weights for less than an hour once a week may lower the risk of heart attack or stroke by 40–70%. The researchers also add that performing weight exercises for more than an hour...
Factors such as age, gender, physical activity, genetics, medical history, body type, and others directly affect not only the desire to lose weight, but also to follow the right diet. Everything is relative, everything is individual. Nevertheless, there are universal...
It is very entertaining to be a sport fan. There is a big variety of sport games that are extremely interesting to follow. Moreover, it is always fun to anticipate the score and watch the enthusiasm live. One of the benefits of being sports fan is using different...
A new study of nearly 18,000 participants found that those with high fitness at middle age were significantly less likely to die from heart disease in later life, even if they were diagnosed with depression. Doctor's Tips: How to Stay Fit While Treating Depression Dr....
MediGoo is attending the largest health/medical industry event in Düsseford, Germany. We welcome you to visit our stand at hall 15 booth E55. Welcome, hope to see you there 15E55.