Graft versus host disease

Graft-versus-host disease (GVHD): Description, Causes and Risk Factors: Abbreviation: GVHD. Alternative Name: GVH disease. GVHDGVHD is a complication that can occur after a bone marrow transplant in which the newly transplanted material attacks the transplant recipient's body. It is mainly observed after allogeneic marrow transplantation and presumably mediated by donor T lymphocytes reactive against the tissue of the recipient. Clinically relevant acute graft-versus-host disease develops in 40-60% of patients given (human leukocyte antigen) HLA-identical marrow grafts within the first 100 days of transplantation. The main target organs are skin, liver, and intestinal tract. Chronic GVHD usually develops 100-500 days after transplantation and affects about 45% of all long-term survivors. In addition the target organs also include lacrimal and salivary glands, mucous and serous membranes. The disease is traditionally graded in 5 stages (0-IV), based on involvement of the skin, liver, and GI tract. When you receive a donor's stem cells (the “graft”), their job is to recreate the donor's immune system in your body (the “host”), but the differences between the donor's marrow and recipient's tissues often cause T cells from the donor's marrow to recognize the recipient's body tissues as foreign. When this happens, the newly transplanted bone marrow attacks the transplant recipient's body and leads to graft-versus-host disease. Risk Factors of GVHD HLA disparity 6/6 > 5/6 > 4/6.
  • Allo stem cell source MRD > UCB > UBM.
  • Donor age.
  • Sex incompatibility.
  • CMV incompatibility.
  • Immune suppression.
Symptoms: Some common symptoms related include Skin: Rash (lichenoid, sclerodermatous, hyperpigmented, hypopigmented, flaky), alopecia, dry eyes and mouth.
  • Joints: Arthralgia, arthritis, contractures.
  • Oral/Ocular: Sj

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