Granulosis rubra nasi

Granulosis rubra nasi: Description, Causes and Risk Factors: ICD-10: L74.8. Abbreviation: GRN. Granulosis rubra nasi is a rare familial disease of children, occurring on the nose, cheeks, and chin, characterized by diffuse redness, persistent hyperhidrosis, and small dark red papules that disappear on diascopic pressure. granulosis rubra nasi The etiology of GRN is obscure, presentation uncommon, benign and chronic course. It occurs in childhood and spontaneous resolution in adolescence, but some cases may persist indefinitely and cysts presenting residual telangiectasias. The pathogenesis is unknown. This is a non-neoplastic disorder of the eccrine sweat glands which is probably the only form of sweat retention. The eccrine glands produce and secrete sweat, a change in the rate of secretion is manifested through one hypohidrosis or hyperhidrosis. The GRN provides a persistent localized hyperhidrosis associated with poor peripheral circulation, causing skin lesions including papules, vesicles and diffuse erythema. GRN have been attributed to various causes of infectious tuberculosis, superficial circulatory disorders, endocrine, autonomic balance disorders and hereditary. Currently, most reported cases are genetically determined, but the mode of inheritance is still unknown. Symptoms: Clinically, it is characterized by the presence of papules, micro-papules, pruritic with vesicles and occasional cysts, associated with diffuse erythema and persistent hyperhidrosis in nasal region, cheeks and chin. Diagnosis: Diagnosis is usually based on physical examination, which include Marked sweating on the tip of the nose is the most conspicuous feature.
  • Redness is seen on the tip of the nose and onto the cheeks, upper lip, and chin. Red areas may be covered by small beads of sweat.
  • Small erythematous macules and papules may occur.
  • Small vesicles or pustules may form at the sweat duct orifices (miliaria crystallina).
  • The tip of the nose is cool and not infiltrated.
  • Poor peripheral circulation and hyperhidrosis of the palms and soles may be noted.
  • If the condition does not resolve completely at puberty, residual telangiectasias and small cysts may occur.
For more accurate diagnosis eliminate the other differential diagnosis and come to conclusion. The differential diagnosis may include acne vulgaris and rosacea, which do not have excessive sweating, the photodermatosis, which are more extensive with no hyperhidrosis, miliaria crystalline and systemic diseases such as lupus erythematosus, lupus vulgaris and leishmaniasis important to consider other clinical manifestations because it has reported the case of a patient who presented with pheochromocytoma associated with granulosis rubra nasi tachycardia. Treatment: There is no local or systemic treatment effective, but can recommend the use of astringent lotions. The use of topical steroids low power are helpful to relieve symptoms. Consult your dermatology for more appropriate treatment options. NOTE: The above information is educational purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.

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