- Grade 2: Dysaesthesia but no pain, severe redness and/or swelling.
- Grade 3: Dysaesthesia with pain, severe redness and/or swelling.
- Grade 4: Pain and impaired function in the activities of daily living, desquamation, blistering and ulceration.
- Blisters, ulcers, or sores on the skin.
- Severe pain.
- Difficulty walking or using the hands.
- Topical dimethyl sulfoxide to help reduce leakage of chemotherapy from the capillaries.
- Vitamin B6 (pyridoxine) to help reduce symptoms.
- Over-the-counter pain relievers, such as acetaminophen (Tylenol), to help relieve pain.
- Take cool showers or baths.
- Avoid exposure to sources of heat, including saunas, sitting in the sun, or sitting in front of a sunny window.
- Avoid activities that cause unnecessary force or friction on the feet, such as jogging, aerobics, and long walks.
- Avoid contact with harsh chemicals used in laundry detergents or household cleaning products.
- Avoid the use of rubber gloves to clean with hot water, as rubber traps heat against your skin.
- Avoid using tools or household items that require you to press your hand against a hard surface, such as garden tools, knives, and screwdrivers.
- Cool your hands and feet with ice packs or cool compresses (wet towel) for 15 to 20 minutes at a time. (Avoid applying ice directly to the skin).
- Elevate your hands and feet when sitting or lying down.
- Carefully pat your skin dry after washing or bathing — try not to rub your skin with a towel.
- Gently apply mild skin care creams to keep your hands moist. Avoid rubbing or massaging lotion into your hands and feet, as this creates friction.
- Wear loose, well-ventilated (air moves through easily) shoes and clothes.
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