- Stage II — Usually a tumor that can mostly be removed by surgery; very small amounts of the cancer are left in the liver.
- Stage III — Usually a tumor that cannot be completely removed, or else; cancer cells are also have been found in the lymph nodes.
- Stage IV — Cancer that has spread to other parts of the body.
- Recurrent — The disease has returned after it has been treated; i.e., It may come back in the liver or in another part of the body.
- Loss of appetite, nausea, abnormal weight loss, diarrhea.
- Changes in the skin color: jaundice evidenced by yellow tone to the skin and whites of the eyes.
- General itching.
- Fever, irritability.
- Abdominal pain.
- Additional blood tests — Blood chemistries, evaluation of liver and kidney functions, and genetic study.
- Biopsy — A sample of tissue removed from the tumor and examined under a microscope; your surgeon may also look at the liver using an instrument called a peritoneoscope, a small tube with a light on the end.
- Alpha-fetoprotein (AFP) test — Alpha-fetoprotein (AFP) levels in the blood can be used to diagnose and follow your child's response to treatment.
- Serum tumor marker tests: Hepatoblastoma often produces a protein which can be detected in the blood. Levels of alpha-fetoprotein (AFP) can be used as a way to determine whether the tumor is responding to treatment (AFP levels decrease), whether there is no evidence of disease, or if there is an indication of relapse (increased levels of AFP).
- Computerized tomography scan (also called a CT or CAT scan) — A CT scan shows detailed images of any part of the body, including the bones, muscles, fat, and organs. CT scans are more detailed than general x-rays.
- Magnetic resonance imaging (MRI) — A diagnostic procedure that uses a combination of large magnets, radiofrequencies, and a computer to produce detailed images of organs and structures within the body.
- Ultrasound (also called sonography) — Ultrasounds are used to view internal organs as they function, and to assess blood flow through various vessels.
- Liver scans — Pictures or x-rays taken after a dye has been injected that is absorbed by liver tissue. These are used to detect tumors and liver abnormalities.
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