- In systemic hematological diseases, the liver is usually involved in extramedullary hematopoiesis. This can result in hepatomegaly. Diffuse hepatomegaly is also expected to occur as a result of malignant cell growth.
- Endothelia and Kupffer cells can be stimulated to considerable proliferation, so that in clinical terms hepatomegaly occasionally results.
- Proliferation of smooth endoplasmic reticulum due to the prolonged induction of the biotransformatory system localized at this site as a result of toxins, chemicals can bring about clinically and sonographically detectable hepatomegaly.
- Hepatocellular storage of abnormal quantities of cholesterol, fat, glycogen, proteins, mucopolysaccharides, copper, iron, etc occasionally leads to pronounced hepatomegaly. Hydropic swelling of the hepatocytes is also included in this category.
- A disorder of the bile flow, particularly in infants leads to extensive hepatomegaly.
- An increase in the extracellular matrix due to collagens, elastin, proteoglycans, glycoprotein, etc also produces various degrees of hepatomegaly.
- Hepatitis caused by a virus — including hepatitis A, B and C — or caused by infectious mononucleosis.
- Nonalcoholic fatty liver disease.
- Alcoholic fatty liver disease.
- A disorder that causes abnormal protein to accumulate in your liver (amyloidosis).
- A disorder that causes copper to accumulate in your liver (Wilson's disease).
- A disorder that causes iron to accumulate in your liver (hemochromatosis).
- A disorder that causes fatty substances to accumulate in your liver (Gaucher disease)
- Fluid-filled pockets in the liver (liver cysts).
- Non-cancerous liver tumors, including hemangioma and adenoma.
- Obstruction of the gallbladder or bile ducts.
- Toxic hepatitis.
- Liver cancer.
- Blockage of the veins that drain the liver (Budd-Chiari syndrome).
- Heart failure.
- Pericarditis (inflammation of the tissue surrounding the heart).
- Take vitamin supplements only as directed, and always discuss them with your doctor.
- Upper abdominal pain, usually right upper abdominal pain.
- Right side flank pain.
- Shaking and chills.
- Yellow skin.
- Yellow eyes.
- Brown urine.
- Clay colored stool.
- Abdominal ultrasound (may be done to confirm the condition if the doctor thinks your liver feels enlarged during a physical exam).
- CT scan of the abdomen.
- Liver function tests (LFTs), including blood clotting tests.
- MRI scan of the abdomen.
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