Hyperamylasemia: Description, Causes and Risk Factors: Elevated serum amylase. HyperamylasemiaAmylase is found in several tissues, most notably the pancreas and the salivary glands. Digestion of your dietary intake of carbohydrates and fat relies on the action of amylase, found in the saliva, to begin the digestion of starches. At the same time, lipase from your gastric secretions breaks down the fat in your food. The normal level for amylase is 0-137 U/L. The finding of elevated serum amylase levels most commonly reflects pancreatic inflammation or injury. However, hyperamylasemia can result from several other acute abdominal events, such as intestinal perforation, ischemia, or infarction. Other well-recognized causes of elevated serum amylase levels include salivary gland disorders; tumors such as ovarian and lung carcinomas; renal failure, which causes reduced amylase clearance; and macroamylasemia. Causes and Risk Factors: Pancreatitis - This can cause amylase and lipase levels to be increased up to 3 times the normal limit.
  • Tumors - Amylase enzyme levels may be increased in some pancreas, salivary, prostate, lung and ovarian tumors.
  • Gall bladder infection - Inflammation of the gallbladder (cholecystitis), may cause increased amylase levels, causing hyperamylasemia.
  • Kidney failure can result in hyperamylasemia.
  • Endoscopic retrograde Cholangiopancreatography (ERCP) procedure can result in hyperamylasemia.
  • Breast cancer may also causes of hyperamylasemia in some cases.
  • Anorexia nervosa and bulimia increased salivary amylase and may lead to Hyperamylasemia.
  • Medications - some medications may lead to pancreatitis, which could cause hyperamylasemia and hyperlipasemia.
You may be at risk for pancreatitis, including hyperamylasemia and hyperlipasemia, if you are: Extremely overweight (obese).
  • Have high triglyceride levels in your blood.
  • Drink too much alcohol.
  • Have been diagnosed with gallbladder stones.
  • Have a family history of pancreatitis.
Symptoms: There are oftentimes no symptoms of hyperamylasemia, unless you develop pancreatitis. Symptoms may include: Nausea or vomiting. Diagnosis: Amylase testing is done on both blood and urine. The laboratory may use any of several testing methods that involve mixing the blood or urine sample with a substance with which amylase is known to react. By measuring the end-product or the reaction time, technicians can calculate the amount of amylase present in the sample. More sophisticated methods separately measure theamylase made by the pancreas and the amylase made by the salivary glands.Hyperamylasemia can be diagnosed by measuring amylase levels in the urine. Methods that may be used to help determine the cause of this desease may include the amylase-to-creatinine clearance ratio (ACR) can help differentiate acute pancreatitis from other conditions. An ACR of greater than 5% suggests acute pancreatitis, ACR of less than 1% suggests macroamylasemia, and if it is in between it may be Hyperamylasemia. hyperamylasemia Treatment: The treatment of hyperamylasemia depends mainly on its cause. If you are experiencing this desease, and are without symptoms, your doctor or healthcare provider may tell you to avoid alcohol and narcotics, and they may closely monitor your laboratory values and symptoms. Medications used to aid in digestion include: Non-steroidal anti-inflammatory (NSAID) and pancreatic enzymes. Disclaimer: The above information is educational purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.


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