Immunoglobulin A deficiency
- Recurrent infections.
- Food allergies.
- Crohn's disease.
- Relation to patient with hypogammaglobulinemia.
- Celiac disease.
- Chromosomal abnormality.
- Possible malignancy.
- Endocrinopathy (any disease caused by disorder of the endocrine glands)
- Hypersplenism (an increased spleen activity causing anemia, increased red blood cell destruction, and spleen enlargement) and thrombocytopenia (abnormally low platelet count).
- Intestinal nodular hyperplasia (excessive formation of intestinal nodes).
- Recurrent giardiasis (protozoan infection).
- Pulmonary hemosiderosis (deposits of iron-containing pigment from hemoglobin in lungs due to red blood cell destruction).
- Rheumatoid arthritis (chronic inflammatory disease causing joint changes and deformities).
- Juvenile rheumatoid arthritis (rheumatoid arthritis affecting juveniles with onset before 16; remission occurs in 75% of patients).
- Systemic lupus erythematosus (chronic inflammation of connective tissues affecting skin, joints, kidneys, and nervous system).
- Thyroiditis (inflammation of the thyroid gland).
- Transfusion reaction.
- Pernicious anemia (anemia due to low intestinal absorption of vitamin B12).
- Dermatomyositis (connective tissue disease with edema, dermatitis, and muscle inflammation).
- Coomb's positive hemolytic anemia (positive for antibodies to part of red blood cell causing anemia due to red blood cell destruction).
- Idiopathic Addison's disease (deficiency of secretions of adrenocortical hormones from the adrenal gland which affects almost all body systems)
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