Langerhans cell histiocytosis
- Pain, swelling or lump in a bone that does not go away, such as on the skin, arms or legs.
- Bone fracture for no clear reason or from only minor trauma.
- Loose teeth when you would not expect this, or swollen gums.
- Ear infection, cysts in the ear or fluid that oozes from the ear.
- Skin rash, such as on the scalp or buttocks.
- Swollen lymph nodes in the neck.
- Liver problems, which may cause jaundice, fluid in the belly, diarrhea or vomiting.
- Bulging eyes or other eye problems.
- Cough and trouble breathing.
- Weight loss for no reason.
- Failure to thrive, which means not gaining weight and growing normally.
- Not wanting to eat or having problems feeding.
- Needing to urinate more often than normal and being very thirsty (signs of a health problem called diabetes insipidus).
- X rays: Your child will need X rays to determine which bones are affected byLangerhans cell histiocytosis. Abone surveyorskeletal survey,which X-rays all the bones in yourchild's body from head to toe, is the most common X-ray used to detectLangerhans cell histiocytosis. If Langerhans cell histiocytosis is suspected in a bone, the area is usually described aslytic,which means that some of the bone has been eaten away by the abnormal Langerhans cells.
- Chemotherapy: Chemotherapy medicines used to kill cancer cells may also help control Langerhans cells. Doctors give some types of these medicines through a vein (intravenously, or by IV). For skin problems, they may apply medicines right on the skin. The doses are lower than used for cancer.
- Radiation: This treatment can help control cells that are damaging bone and making it weak. The doses are lower than for cancer.
- Surgery: Doctors may operate to remove the excess Langerhans cells (used mostly for bones).
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