Lenticular progressive disease

Lenticular progressive disease: Description, Causes and Risk Factors: Lenticular progressive disease is widespread erythema and scaling of the skin caused by preexisting skin disorders, drugs, cancer, or unknown causes. Lenticular progressive diseaseLenticular progressive disease is a manifestation of rapid epidermal cell turnover. Its cause is unknown, but it most often occurs in the context of preexisting skin disorders (eg, atopic dermatitis, contact dermatitis, seborrheic dermatitis, psoriasis, pityriasis rubra pilaris), use of drugs (eg, penicillin, sulfonamides, isoniazid, phenytoin, barbiturates), and cancer (eg, lymphoma, mycosis fungoides, leukemia, and, rarely adenocarcinomas). Up to 25% of patients have no identifiable underlying cause. Bacterial superinfection can complicate exfoliative dermatitis. Several factors may be responsible for the causation of this extensive skin disorder. Subtle/sudden generalization of preexisting dermatoses may be an intriguing dilemma, and may reflect an individual variation. A detailed outline of a patient's history to elicit possible triggering events, namely infections, drug ingestion, topical application of medicaments, sun/ultraviolet light exposure, and other factors, may be imperative. It is also challenging to manage the condition, because the intricate process puts an extensive strain on an already compromised body system. Furthermore, it is probable that the original dermatosis may be masked by extensive erythema/scaling, thus making it difficult to obtain a clear-cut diagnosis. Lenticular progressive disease may ultimately be one of the clinical expressions of reticuloendothelial neoplasms and internal blood vessel malignancies. The latter invariably affect older individuals, and lenticular progressive disease is considered to be a salient cutaneous marker of internal malignancy. Its incidence is around 1%. Lymphomas in general and T-cell lymphoma [comprising mycosis fungoides and S


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