Liquefactive necrosis Symptoms:1. Changes in mental status
- Decreasing responsiveness.
- Eventual coma.
- Slow thought processes.
Signs:The affected area is soft with liquefied centre containing necrotic debris. Later, a cyst wall is formed. Microscopically, the cystic space contains necrotic cell debris and macrophages filled with phagocytosed material. The cyst wall is formed by proliferating capillaries, inflammatory cells, and gliosis (proliferating glial cells) in the case of brain and proliferating fibroblasts in the case of abscess cavity.
Diagnosis:A brain and nervous system (neurological) exam will usually show increased intracranial pressure and problems with brain function.Tests to diagnose a liquefactive necrosis may include:
- Head CT scan.
- Electroencephalogram (EEG).
- MRI of head.
- Blood cultures.
- Complete blood count (CBC).
- Testing for the presence of antibodies to organisms such as Toxoplasma gondii and Taenia solium.
Treatment:Treatment of liquefactive necrosis typically involves two distinct processes. Usually, the underlying cause of the necrosis must be treated before the dead tissue itself can be dealt with. Even after the initial cause of the necrosis has been halted, the necrotic tissue will remain in the body. The body's immune response to apoptosis, the automatic breaking down and recycling of the cell material, is not triggered by necrotic cell death.Antibiotics will be prescribed. Antibiotics that work against a number of different bacteria (broad spectrum antibiotics) are most commonly used. You may be prescribed several different types of antibiotics to make sure treatment works.Antifungal medications may also be prescribed if the infection is likely caused by a fungus.The standard therapy of liquefactive necrosis is surgical removal of necrotic tissue. Depending on the severity of the necrosis, this may range from removal of small patches of skin, to complete amputation of affected limbs or organs. Chemical removal, via an enzymatic debriding agent, is another option. In select cases, special maggot therapy has been utilized with good results.NOTE: The above information is for processing purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.
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