Description, Causes and Risk Factors:
ICD-10-DC: Q14.1 (congenital).
An overgrowth of glial tissue compensating for aplasia of sensory elements.
Retinal dysplasia consists of an abnormal proliferation of developing retina, producing tubular structures with a rosette-like appearance in cross section. It appears to be associated with a single pathogenetic basis: the separation of the retina during a critical stage of its differentiation from its underlying pigment epithelium.
The pathogenesis of retinal dysplasia include the following:
Secondary to detachment of the retina from the pigment epithelium.
Occurring in an otherwise normal location over areas devoid of pigment epithelium.
In situ dysplastic process with no evidence that the dysplastic retina has ever been separated from its underlying epithelium.
Resulting from hyperplastic extension of the retina into "abnormal" sites away from its pigment epithelium.
The underlying feature of each of these processes is the absence of a presumed normal histogenetic control by the pigment epithelium on the developing retina. Dysplastic changes appear to be intermediate between a receptor that has developed normally and one that has followed uncontrolled, neoplastic growth. Muller fibers contribute to dysplastic rosette formation but not retinoblastoma rosette formation.
Retinal dysplasia may also be associated with congenital anomalies (13%), or with chromosomal abnormalities like Trisomy 13, or systemic findings such as Norrie's disease (x-linked recessive).
The disease is very rare and affects 1 in millions.
Folds in the retina.
Ridges in the retina.
Detachment of the retina, complete or focal.
Patchy abnormal discoloration.
Theultrasonographic and tomographic findings are helpfulin the diagnosis of suspected retinal dysplasia. A thoroughphysical examination is needed to rule out systemic abnormalities associated with the disease. Early screening willbe of help in genetic counseling of the parents.
The diagnosis may be confirmed by Funduscopic appearance& Fluorescein angiographic appearance.
There is no known cure. If the disease produces no exudation or hemorrhage, in most cases, they may be simply observed. Some dysplasias pulsate due to the arterial pulse pressure, and this feature may represent an increased risk of bleeding in the near future. If exudation or hemorrhage threaten or affect central vision, several management options exist depending on the clinical situation; laser photocoagulation, Nd:YAG laser, pneumatic displacement of hemorrhage, and vitrectomy with surgical evacuation of blood have all been employed in the treatment of retinal dysplasia. Risks and benefits positive, must be carefully discussed with your Eye specialist.
NOTE: The above information is educational purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.
DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.
Here is the list of nine user-friendly gym machines for women that are intimidated by barbells, bumper plates, and squat racks by Robin Cortez, director of team training for Chuze Fitness, which has clubs in California, Colorado and Arizona: Smith machine — used for...
A new study from Imperial College London suggests that higher levels of iron may cut the risk of clogged arteries. On the other hand, they are linked to a higher risk of blood clots. Within the scope of the study, the scientists used genetic data from 500,000 people...
When it is so hot outside you still can find hundreds of ways to cool yourself and drinking a mocktail is one of them. Here are few wonderful recipes for you to try. Kiwi Sour 1 oz orange juice 3 slices kiwi 0.75 oz demerara green tea syrup 0.75 oz lime juice 1 oz...read more
Many people are motivated for active sports in spring. However, before you buy a membership, you should check which exercises are useful to you and which ones should not be done in any way. Unfortunately, nowadays there are practically no people with an absolutely...read more
In childhood, many of us dreamed of learning to jump high. Now, after years, it became easier - Kangoo Jumps has appeared. This is one of the relatively new, but quickly gaining popularity types of fitness training. There are several advantages of jumpers. ...read more