Scarring alopecia: Description, Causes and Risk Factors:Alternative Name: Scarring alopecia, cicatricial alopecia.Scarring alopecia refers to a diverse group of rare disorders that destroy the hair follicle, replace it with scar tissue, and cause permanent hair loss. During the active, evolving stage of hair loss, patches of scarring alopecia commonly appear red and inflamed at the base of the hair shaft. Sometimes crops of pustules are noted. Some types of scarring alopecia destroy the hairs deep within the scalp, without inflammation visible on the skin surface. While some types of scarring alopecia result in rapid hair loss, slow progression of hair loss is more common.This disease affect both men and women, most commonly young adults although all ages may be affected. There have been a few reports of cicatricial alopecia occurring in a family.In general scarring alopecia is the result of destruction of the hair follicle causing it to be replaced by scar tissue. Diseases that cause cicatricial alopecia include systemic lupus erythematosus, lichen planus, persistent bacterial or fungal infections, and skin cancer. The skin may also be damaged from burns, other physical injuries, and radiation therapy.Types may include:Primary cicatricial alopecia.
Secondary scarring alopecia.
In primary scarring alopecia, the hair follicles are destroyed by an inflammatory process, which usually involves lymphocytes, neutrophils or other inflammatory cells. Such a condition can be caused by autoimmune disorders. Depending on the type of inflammatory cells involved, primary cicatricial alopecia is further classified into three main types, which are known as lymphocytic, neutrophilic and mixed alopecias.On the other hand, secondary scarring alopecia results from factors like burn, injury or severe infections that leave scars on the scalp and cause hair loss on the affected areas.It is easy to identify a case of severe cicatricial alopecia because there will be rough patches on the surface of the scalp made up of small blood vessels and connective tissue.Symptoms:Clinical signs may include:Obvious areas of baldness.
Lack of follicular ostia.
Involved hairs oftenprotrude from the scalp atan odd oblique angle or inabnormal groups of hair.
Itching and a burning sensation present.
Redness, fluid filled blisters or pustules and scarring may occur in the affected area.
Diagnosis:A careful physical examination, scalp biopsies and blood tests can be helpful in order to establish the correct diagnosis and to suggest the most appropriate treatment for scarring alopecia.Biopsies are best done of active, inflamed sites on the scalp which still have remaining hair. A biopsy of an older scarred area may be helpful to predict the likelihood of re-growth of hair, and to help establish the diagnosis by evaluating the pattern of scar formation. If certain types of the disease are suspected, your doctor may send a biopsy specimen for additional special tests including direct immunofluorescence, and special stains for bacteria, fungi and elastic tissue. In some infectious disorders that can cause scarring alopecia, a biopsy must be sent for tissue culture.Treatment:Treatment for the disease remains poor. The main goals of treatment for cicatricial alopecia are to prevent further hair loss and to eradicate or at least lessen the redness, scale and itching associated with the process. There are no current FDA approved treatments for scarring alopecia although the NAHRS (North American Hair Research Society) has been working to initiate interest in this area among industry sponsors. All treatment now for scarring alopecia is strictly based on the experience of the prescribing physician or anecdotal reports as there has never been any multicenter clinical trial in this area.Treatment of the lymphocytic group of the disease involves use of antiinflammatory medications. The goal of treatment is to decrease or eliminate the lymphocytic inflammatory cells that are attacking and destroying the hair follicle. Oral medications may include hydroxychloroquine, doxycycline, mycophenolate mofetil, cyclosporine, or corticosteroids. Topical medications may include corticosteroids, topical tacrolimus, topical pimecrolimus, Derma-Smoothe/FS scalp oil, triamcinolone acetonide (a corticosteroid) may be injected into inflamed, symptomatic areas of the scalp.Treatment of the neutrophilic group of scarring alopecias is directed at eliminating the predominant microbes that are invariably involved in the inflammatory process. Oral antibiotics are the mainstay of therapy, and topical antibiotics may be used to supplement the oral antibiotics. Isotretinoin is sometimes helpful in controlling the neutrophilic group, especially dissecting cellulitis.Treatment of the mixed group of cicatricial alopecia may include antimicrobials, isotretinoin (especially for folliculitis keloidalis), and anti-inflammatory medications.You should discuss any treatment with your dermatologist who will also explain potential side effects of the treatment.Surgical treatment is not an option in most cases except under certain conditions if the disease has been inactive for many years and the area of hair loss is small, then surgical removal of the scarred scalp and/or hair transplants may be considered for cosmetic benefit.Disclaimer: The above information is educational purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.
The first randomized clinical trial, performed by the researchers from the University of Minnesota Medical School, shows that hydroxychloroquine is not able to prevent the development of COVID-19. The randomized placebo-controlled trial aimed to test if...
Scientists have successfully transplanted functional miniature livers into rats. The organs were grown in the lab from reprogrammed human skin cells donated by the volunteers. Researchers transplanted organs into five rats, and the tiny livers appeared to be...
No Results Found
The page you requested could not be found. Try refining your search, or use the navigation above to locate the post.
When it is so hot outside you still can find hundreds of ways to cool yourself and drinking a mocktail is one of them. Here are few wonderful recipes for you to try. Kiwi Sour 1 oz orange juice 3 slices kiwi 0.75 oz demerara green tea syrup 0.75 oz lime juice 1 oz...
Many people are motivated for active sports in spring. However, before you buy a membership, you should check which exercises are useful to you and which ones should not be done in any way. Unfortunately, nowadays there are practically no people with an absolutely...
In childhood, many of us dreamed of learning to jump high. Now, after years, it became easier - Kangoo Jumps has appeared. This is one of the relatively new, but quickly gaining popularity types of fitness training. There are several advantages of jumpers. ...
Privacy & Cookies Policy
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.