Description, Causes and Risk Factors:
Alternative Name: Majocchi granulomas.
Tinea profunda is also known as nodular granulomatous perifolliculitis, is an uncommon fungal folliculitis. It has been described as, “certain superficial fungus diseases which sometimes exhibit fungal elements invading the epidermis, pilosebaceous follicles and dermis to mimic deep cutaneous mycotic disorders.”
Tinea profunda is observed among immunocompetent and immunocompromised patients and is caused by dermatophytes, particularly Trichophyton rubrum, which may be responsible for 50% of cases. Other causes may include T. mentagrophytes and Epidermophyton floccosum. Experts do not know whether these granulomas appear in response to the organism itself, or after the release of follicular contents. It commonly occurs in young women that shave their legs frequently.
The mechanism by which it occurs is yet unknown although reports suggest it may occur after localized trauma that alters the hair follicle and enables the entrance of the microorganism.
Tinea profunda has two clinical presentations, among immunocompetent patients it displays follicular papules and among immunocompromised patients a subcutaneous nodular type is observed.
Symptoms include patches on any hairy area, such as the scalp, face, forearms, hands, and legs. Tinea profunda may be worsened by shaving legs in an upward direction, which causes the hair follicles to be inoculated with athlete's foot fungus. The lesions may first appear as single or multiple oval patches that evolve into pustules and nodules with or without background redness and scaling.
If the condition is associated with the use of topical steroids, they may be affected by the complications of topical steroid therapy, including atrophied skin and spidery veins, rosacea, or patches of loss of color on the skin that looks like leprosy.
Based on the clinical morphology, the differential diagnosis largely includes other conditions that follow a follicular pattern, such as variations of folliculitis, acne, pseudofolliculitis barbae, eosinophilic pustular folliculitis and acne keloidalis.
Fungal elements can be viewed on H&E (hematoxylin and eosin stain), but PAS (periodic acid-Schiff stain) and GMS (Gomori methenamine silver stain can also be used.Histology alone cannot identify the causative organism, but fungal culture can confirm the suspected fungus.
Tinea profunda usually responds to topical antifungal or drying powders, such as those that contain miconazole, clotrimazole, or similar ingredients. Severe or chronic infection may require further treatment by a doctor. Stronger, prescription topical antifungal medications, such as ketoconazole or sulconazole, may be needed. In some cases, topical corticosteroids may be added to the topical antifungals. Antibiotics may be needed to treat secondary bacterial infections.
NOTE: The above information is educational purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.
DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.
It is well known that our overall health and wellbeing are totally dependable on what we eat. That is why a healthy diet plays a significant role in keeping the body healthy. Day after day, scientists all over the world make new discoveries proving that certain...
A new study finds that brain volumes of people who regularly eat vegetables, fruit, and fish are on average 2ml greater than brain volumes of those who often drink sugary beverages. A brain volume reduction of 3.6ml equals to one year of aging. For the study, the...
Quiz about this article
0 of 2 questions completed
Please answer on few questions to make our service more useful
You have already completed the quiz before. Hence you can not start it again.
Quiz is loading...
You must sign in or sign up to start the quiz.
You have to finish following quiz, to start this quiz:
0 of 2 questions answered correctly
Time has elapsed
You have reached 0 of 0 points, (0)
Question 1 of 2
Was this article useful for you?Correct
Thanks for your feedback!Incorrect
Thanks for your feedback!
Question 2 of 2
What else information about this disease you want to know ?Correct
Thanks for feedback!Incorrect
Thanks for feedback!
Good weather is the best reason to do outdoor sports, which will help not only lose weight, but also will strengthen health. Bicycle The sun dries out the local paths, so you can safely sit on your favorite bike and confidently twist the pedals, where the eyes look....read more
First aid for injuries consists of simple rules that need to be clearly implemented. If this is a closed injury, you need to immobilize the injured limb, otherwise the person may lose consciousness from a painful shock. If you need to get to the emergency room...read more
Many people spontaneously decide starting to do sport, while others weigh all the pros and cons for a log time. But almost all of them make the same mistakes, listening to the advice of non experts. There are 10 anti-tips for those who want to do plan to do some sport...read more