Vesicular stomatitis virus

Vesicular stomatitis virus

Description, Causes and Risk Factors:

an RNA virus of the genus Vesiculovirus, in the family Rhabdoviridae, causing vesicular stomatitis in horses, cattle, sheep, and pigs, and sometimes in humans.

Vesicular stomatitis is a viral disease caused by 2 distinct serotypes of vesicular stomatitis virus. Vesiculation, ulceration, and erosion of the oral and nasal mucosa and epithelial surface of the tongue, coronary bands, and teats are typically observed in clinical cases, along with crusting lesions of the muzzle, ventral abdomen, and sheath. Clinical disease has been observed in cattle, horses, and pigs and very rarely in sheep, goats, and llamas. Serologic evidence of exposure has been found in many species including cervids, nonhuman primates, rodents, birds, dogs, antelope, and bats. The viruses are zoonotic and may cause influenza-like disease in people working in close contact with the virus (eg, laboratory exposure, direct contact with lesions in infected animals).

The viruses are members of the family Rhabdoviridae and genus Vesiculovirus. Vesicular stomatitis viruses are the prototypes of the Vesiculovirus genus. They are bullet shaped and generally 180 nm long and 75 nm wide. The genomic structure is a single strand of negative sense RNA composed of 5 genes (N, P, M, G, and L, representing the nucleocapsid protein, phosphoprotein, matrix protein, glycoprotein, and the large protein, respectively). Although there are many members of the Vesiculovirus genus, the New Jersey and Indiana serotypes are of particular interest in the Western hemisphere. These 2 viruses are similar in size and morphology but generate distinct neutralizing antibodies in infected animals. They have both been isolated in recent outbreaks in the USA.

Vesicular stomatitis is seen sporadically in the USA. Outbreaks historically occurred in all regions of the country but since the 1980s have been limited to southwestern states. Vesicular stomatitis viruses are endemic in South America, Central America, and parts of Mexico but have not been seen naturally outside the Western hemisphere. The virus can be transmitted through direct contact with infected animals with clinical disease (those with lesions) or by blood-feeding insects. In the southwestern USA, black flies (Simulidae) are the most likely biologic insect vector. In endemic areas, sand flies (Lutzomyia) are proven biologic vectors. Other insects may act as mechanical vectors. The prevalence of clinical cases in a herd is generally low (10-20%), but seroprevalence within the herd may approach 100%. No reservoir or amplifying host of vesicular stomatitis viruses has been identified.


The incubation period is 2-8 days and is typically followed by a fever. Ptyalism (excessive flow of saliva) is often the first sign of disease. Vesicles in the oral cavity are rarely observed in naturally occurring cases due to rupture soon after formation; therefore, ulcers are the most common lesion observed during primary examination. Ulcers and erosions of the oral mucosa, sloughing of the epithelium of the tongue, and lesions at the mucocutaneous junctions of the lips are commonly seen in both cattle and horses. Ulcers and erosions on the teats are not uncommon in cattle and may result in secondary cases of mastitis in dairy cows. Coronitis with erosions at the coronary band are observed in cattle, horses, and pigs with subsequent development of lameness. Crusting lesions of the muzzle, ventral abdomen, sheath, and udder of horses are typical during outbreaks in the southwestern USA. Loss of appetite due to oral lesions and lameness due to foot lesions are normally of short duration, as the disease is generally self-limiting with complete resolution within 10-14 days. Virus neutralizing antibodies to either serotype persist, potentially for ?5 year, but re-infection can occur following a second exposure.


In most areas, including the USA, vesicular stomatitis is a reportable disease. Samples for diagnostic purposes are generally taken by regulatory veterinarians and are tested by government laboratories. Diagnosis is based on the presence of typical clinical signs and either antibody detection through serologic tests, viral detection through isolation, and/or detection of viral genetic material by molecular techniques. Samples for viral isolation may include vesicular fluid, epithelial tags from lesions, or swabs of lesions. Vesicular stomatitis viruses are easily propagated in cell culture. Three commonly used serologic tests are competitive ELISA, virus neutralization, and complement fixation. PCR may also be used to identify the virus. Of primary concern in diagnosis is differentiation of vesicular stomatitis from clinically indistinguishable but much more devastating viral diseases including foot-and-mouth disease, swine vesicular disease, and vesicular exanthema of swine. Horses are not susceptible to foot-and-mouth disease.


No specific treatment is available or warranted. Cachexia can be avoided by providing softened feeds. Cleansing lesions with mild antiseptics may help avoid secondary bacterial infections. Management factors suggested to reduce risk of exposure to the virus include limiting time on pasture, providing shelters or barns during insect feeding times, and implementing other procedures that reduce animal contact with insects including application of insecticides. When affected animals are identified, they should be isolated, and movement of other animals from the affected premises restricted. Vesicular stomatitis is a reportable disease in most areas, including the USA, so animal health officials must be notified when it is suspected. Commercially produced vaccines are not available in the USA, but vaccines are available in some Latin American countries.

NOTE: The above information is for processing purpose. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition.

DISCLAIMER: This information should not substitute for seeking responsible, professional medical care.


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