Arginine Can Make Radiation Therapy for Cancer More Efficient

A randomized clinical trial, carried out by a team of investigators at Weill Cornell Medicine and Angel H. Roffo Cancer Institute, U.S., showed that using arginine, one of the amino-acid building blocks of proteins, increased the effectiveness of radiation therapy in cancer patients with brain metastases.Arginine Can Make Radiation Therapy for Cancer More Efficient

In this trial, a group of 31 patients with brain metastases received arginine in oral form prior to standard radiation therapy. Approximately 78% had a complete or partial response in their brain tumors over the follow-up period of up to four years, and only 22 % of the 32 patients who received a placebo prior to radiotherapy had such a response.

Senior author Dr. Leandro Cerchietti, an associate professor of medicine in the Division of Hematology and Medical Oncology, who participated in designing and implementing the trial, says: “Based on these findings we should continue to investigate arginine in combination with radiotherapy but also in combination with chemotherapy or immunotherapy, and even arginine on its own.”

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