Coronavirus-Neutralizing Antibodies Successfully Tested in Animals

A team of scientists, led by researchers Scripps Research Institute, isolated super-potent coronavirus-neutralizing antibodies from COVID-19 patients and successfully tested them in animals.Coronavirus-Neutralizing Antibodies Successfully Tested in Animals

For this research, a group of scientists took blood samples from patients who had recovered from mild-to-severe COVID-19. At the same time, another group developed test cells that express ACE2, the receptor that the current coronavirus uses to get into human cells.

In a set of experiments, the researchers tested whether antibody-containing blood from the patients could bind to the virus and block it from infecting the test cells. The scientists managed to isolate more than 1,000 distinct antibody-producing immune cells, or B cells, each of which produced a distinct anti-SARS-CoV-2 antibody.

Study co-senior author Dennis Burton, Ph.D., the James and Jessie Minor Chair in Immunology in the Department of Immunology & Microbiology at Scripps Research, says: “That discovery gives us hope that we will eventually find broadly neutralizing antibodies that provide at least partial protection against all or most SARS coronaviruses, which should be useful if another one jumps to humans.”

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