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Diabetes Drugs May Lower the Risk of Age-related Macular Degeneration

A new meta-analysis, performed by the research team from the University of Bonn, Germany, finds that lipid-lowering drugs and antidiabetic drugs are associated with a lower risk of age-related macular degeneration (AMD).

For the study, the scientists analyzed records from 38,694 patients, taking part in 14 studies that included data on systemic medication use and AMD in various European countries, such as France, Germany, Greece, Ireland, Italy, Norway, Portugal, Russia, and the United Kingdom.

The analysis has shown that lipid-lowering drugs and antidiabetic drugs were associated with 15% and 22% lower AMD prevalence.

Lead author Dr. Matthias Mauschitz, Ph.D., says: “Various studies reported high oxidative stress and an increased general inflammation to result in a breakdown of specific cell functions in the retina, which may contribute to AMD development. LLD interferes [with] lipid metabolism by reducing blood levels of certain metabolites such as low-density lipoprotein (LDL) and cholesterol. Both LLD and antidiabetic drugs, particularly metformin, have been reported to exhibit anti-inflammatory effects and reduce oxidative stress.”

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