Environmental Conditions May Influence Antidepressant Efficiency
Selective serotonin reuptake inhibitors (or SSRIs) help in treatment of moderate and severe depression, as well as other mental health conditions. They work increasing levels of serotonin in the brain. A team of European researchers suggest that antidepressant efficiency is different in some people (or don’t work at all) due to the environment conditions. They tested their new theory in stressed mice.
Results of the study indicated that those mice that were kept in more comfortable conditions showed higher expression of pro-inflammatory cytokines and decreased anti-inflammatory genes, as well as showing fewer signs of depression, compared to the stressed mice. And the stressed mice represented lower pro-inflammatory cytokines and higher anti-inflammatory gene expression, and more signs of depression.
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