Experimental COVID-19 Vaccine mRNA-1273 Is Safe and Elicits Response

An experimental vaccine, mRNA-1273, designed to protect against the novel coronavirus was generally well tolerated and prompted neutralizing antibody activity in healthy adults, according to the results of the NIAID-sponsored Phase 1 trial, published in the New England Journal of Medicine.Experimental COVID-19 Vaccine mRNA-1273 Is Safe and Elicits Response

The first participant received the candidate vaccine on March 16 at Kaiser Permanente Washington Health Research Institute in Seattle. The interim report details the initial findings from the first 45 participants ages 18 to 55 years enrolled at the study sites in Seattle and at Emory University in Atlanta.

Three groups of 15 participants received two intramuscular injections, 28 days apart, of either 25, 100, or 250 micrograms of the experimental vaccine. All the participants received one injection; 42 received both scheduled injections.

Two doses of the vaccine prompted high levels of neutralizing antibody activity that were above the average values seen in convalescent sera received from individuals with confirmed COVID-19.

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