Scientists Found Gene Responsible for Brain Aging
A team of researchers from Columbia University Medical Center found a common genetic variant that significantly affects normal brain aging in senior adults, beginning at about age 65, and able to change the risk for neurodegenerative diseases.
For the study, the researchers analyzed genetic data from autopsied human brain samples taken from 1,904 people without a neurodegenerative disease. Then they compared these data to the average transcriptome of people of the same age looking at 100 genes whose expression was found to increase or decrease with aging. Using this method, the scientists managed to identify the variant TMEM106B. About 1/3 of people have two copies and another 1/3 have one copy.
Researchers believe that these findings could point toward a new biomarker for the evaluation of anti-aging interventions and help find new ways of prevention or treatment of such age-associated disorders as Alzheimer’s disease.
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