Imbalance of Lipids in Brain Cells May Trigger Parkinson’s Disease

Scientists from the Neuroregeneration Institute at McLean Hospital in Belmont, USA, have found that people diagnosed with Parkinson's disease have excess amounts of lipids, or fatty molecules, inside brain cells, and this may cause inflammation.Imbalance of Lipids in Brain Cells May Trigger Parkinson's Disease

For the study, the researchers compared postmortem brain tissue from 26 individuals with Parkinson's disease with 23 control individuals without the condition. They found that the brain tissue from people with the condition contained an accumulation of lipids inside dopamine nerve cells, while people without the condition had a deficiency of lipids within astrocytes in the same samples.

The researchers conclude in their paper: "Therapies and agents that reverse the pathological cell-type-specific lipid distribution in the [substantia nigra of people with Parkinson’s] could serve to prevent and reduce the progression of [Parkinson’s disease] and related neurodegenerative disorders."

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