Newly-Designed DNA Tool May Fight Multidrug-Resistant Cancer Cells
A team of scientists from the National Center for Nanoscience and Technology in Beijing, China, developed a DNA platform able to carry chemotherapy drugs into specific cancer cells as well as silence the cells’ drug-resistant genes.
The team has successfully tested the ability of the DNA platform to selectively deliver RNA transcription templates and the chemotherapy drug doxorubicin in cell cultures and then in mice with multidrug-resistant tumors.
The received results demonstrated that the DNA tool was efficient both at the selective delivery and release of the two items which also led to a highly-selected tumor kill rate.
The authors conclude in their paper: “This tailored DNA nanoplatform, which combines RNAi therapy and chemotherapy, provides a new strategy for the treatment of multidrug-resistant tumors.”
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