Pomegranate May Help in Treatment of Inflammatory Bowel Disease
Researchers from the University of Louisville in Kentucky suggest that natural polyphenols found in pomegranate can fight symptoms of inflammatory bowel disease (IBD). Polyphenols are also present in berries such as strawberries, blackberries, and raspberries.
The scientists found a metabolite named urolithin A (UroA) is produces as a result of polyphenols in fruits and gut bacteria interacting. Using animal model, the researchers demonstrated UroA and UAS03 increase proteins that tighten epithelial cell junctions in the gut.
The first study author Dr Rajbir Singh comments: “The general belief thus far in the field is that urolithins [such as UroA and UAS03] exert beneficial effects through their anti-inflammatory, anti-oxidative properties. We have for the first time discovered that their mode of function also includes repairing the gut barrier dysfunction and maintaining barrier integrity.”
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