Scientists Developed Experimental mRNA Vaccine Against Lyme Disease

In the Fikrig Lab, researchers from the Yale School of Medicine are working on the development of a new mRNA vaccine that trains the human immune system to recognize the saliva from tick bites and may prevent ticks from feeding on and transmitting tick-borne diseases to people.Sceintists Developed Experimental mRNA Vaccine Against Lyme Disease

The researchers created an mRNA vaccine called 19ISP that teaches cells to recognize 19 selected proteins in the saliva that the deer or black-legged tick leaves on the skin during a bite. The vaccine targets proteins naturally found in the tick’s spit.

During the experiments, the scientists saw that guinea pigs jabbed with 19ISP experienced skin redness after they were bitten, indicating that the immune system was activated and recruited inflammatory cells to the site to fight off infection.

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