Alzheimer’s Nasal Spray Vaccine Is Ready for Human Trials

Last week, Brigham and Women's Hospital announced that they are ready to start the first human trial of a nasal vaccine for Alzheimer's aimed to prevent or slow the progression of the condition.Scientists Are Ready for Human Trials of Alzheimer's Nasal Spray Vaccine

In this small trial, 16 people aged 60–85 with marked Alzheimer's symptoms will receive two doses of the vaccine one week apart. But it builds on decades of research suggesting that stimulating the immune system can help clear out beta-amyloid plaques in the brain.

The sticky plaques which are a hallmark of Alzheimer's disease form when pieces of beta-amyloid protein accumulate between nerve cells, potentially disrupting the ability to think or recall information. The vaccine sprays the drug Protollin directly into the nose, aiming to activate immune cells to remove the plaque.

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