Scientists Developed Nanobodies Able to Stop SARS-CoV-2

A team of scientists at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen (Germany) and the University Medical Center Göttingen (UMG) has developed mini-antibodies that efficiently block the coronavirus SARS-CoV-2, as well as its dangerous new variants: Alpha, Beta, Gamma, and Delta mutants.Scientists Developed Nanobodies Able to Stop SARS-CoV-2

These nanobodies are able to bind and neutralize the virus up to 1000 times more efficiently than mini-antibodies, developed previously. The researchers optimized their mini-antibodies for stability and resistance to extreme heat, making them promising agents to treat COVID-19.

Matthias Dobbelstein, professor and director of the UMG's Institute of Molecular Oncology, says: “Our nanobodies can withstand temperatures of up to 95 °C without losing their function or forming aggregates. For one thing, this tells us that they might remain active in the body long enough to be effective. For another, heat-resistant nanobodies are easier to produce, process, and store.”

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