Scientists Developed Urine Test to Diagnose Kidney Transplant Rejection

A new study, completed by scientists from Brigham and Women's Hospital and Exosome Diagnostics, U.S., proposes a noninvasive test to diagnose kidney transplant rejection using exosomes, tiny vesicles containing mRNA, from urine samples.Scientists Developed Urine Test to Diagnose Kidney Transplant Rejection

For their study, researchers collected urine samples from 175 patients who were undergoing kidney biopsies advised by physicians and isolated urinary exosomes from the immune cells of the newly transplanted kidneys. From the vesicles, they isolated protein and mRNA and identified a rejection signature, a group of 15 genes, that could indicate normal kidney function or rejection.

Jamil Azzi, MD, associate physician in the Division of Renal Transplant at the Brigham and an associate professor of Medicine at Harvard Medical School, says: “Our goal is to develop better tools to monitor patients without performing unnecessary biopsies. We try to detect rejection early, so we can treat it before scarring develops. If the rejection is not treated, it can lead to scarring and complete kidney failure. Because of these problems, recipients can face life-long challenges.”

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