Study in Mice: Cholesterol May Help Cancer Spread

Researchers from Duke University School of Medicine in Durham, U.S., have investigated the link between high cholesterol and cancer cell growth and spread. According to the study, high cholesterol levels fuel cancer cells by increasing resistance to a form of cell death.

For their study, the researchers used cell lines and mice models. The scientists noticed that exposure to 27HC, which is a derivative of cholesterol obtained through oxidation and implicated in cancers, resulted in the growth of tumors that were highly metastatic.

Lead researcher Dr. Donald McDonnell, Ph.D., says: “There is an abundance of epidemiological evidence linking hypercholesterolemia to poorer outcomes in [people] with most cancers, [and now] we think we have found why and have defined a completely new way to treat these cancers.”


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