Study: mRNA Booster Vaccine Offers Best Protection Against Omicron

A new study, conducted by a team of researchers from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, finds that a booster dose of an mRNA COVID-19 vaccine provides the best immune protection from the Omicron variant.Study mRNA Booster Vaccine Offers Best Protection Against Omicron

The scientists created a pseudovirus of the original strain (wild-type)Trusted Source, Delta, and Omicron SARS-CoV-2 viruses. Then, they used the assay to test blood samples from 239 vaccinated participants (111 were vaccinated with Pfizer-BioNTech, 88 — with Moderna, and 40 — with Johnson & Johnson).

All study participants have been divided into 5 groups:

  • those who received the primary vaccination series in the past 3 months and never developed COVID-19 (recently vaccinated)
  • those who received the primary vaccination series in the past 6–12 months and never developed COVID-19 (distantly vaccinated)
  • those who received the primary vaccination series in the past 6–12 months and developed COVID-19 (distantly vaccinated with infection)
  • those who received a booster dose of the Pfizer or Moderna vaccine in the past 3 months and never developed COVID-19 (booster)

The analysis of the collected data showed that only the participants who received the booster dose had robust Omicron pseudovirus neutralization, while the other groups showed substantial decreases in neutralization capability.

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