Type 2 Diabetes May Accelerate Brain Aging and Cognitive Decline

A large-scale study, recently published in eLife, finds that type 2 diabetes is associated with accelerated brain aging and cognitive decline.Type 2 Diabetes May Accelerate Brain Aging and Cognitive Decline

The research team analyzed data of more than 20,000 people from the UK Biobank matching people with type 2 diabetes mellitus (T2DM) with healthy controls (HCs) for age, sex, education, and hypertension status. All participants were between 50 and 80 years old.

Later, they performed a meta-analysis of 34 cognitive and 60 neuroimaging studies to determine whether these studies backed up their findings.

Having analyzed the received data, the scientists found a linear decrease in gray matter with age for brain atrophy. This decrease was greater in those with T2DM than in HCs. Also, they observed the most severe neurocognitive effects in participants who had the longest duration of type 2 diabetes.

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