Brisk Walking May Halt the Biological Aging Process

A new study, conducted by scientists from the University of Leicester in the UK, finds that brisk walking is associated with a slower biological aging process as measured by leukocyte telomere length (LTL).Brisk Walking May Halt the Biological Aging Process

For their study, a team of researchers used data from the UK Biobank database and analyzed data on 405,981 middle-aged individuals. The genetic analysis they performed included a causal link between brisk walking and LTL, apart from any other physical activity.

Lead study author Paddy Dempsey from the University of Leicester  says: “This suggests measures such as a habitually slower walking speed are a simple way of identifying people at greater risk of chronic disease or unhealthy aging, and that activity intensity may play an important role in optimizing interventions.”

Scientists Managed to Reverse Aging in Mice with Grape Seed Extract

In a new study, published in the journal Nature Metabolism, the scientists suggest that a component of grape seed extract procyanidin C1 (PCC1) can be used as a potentially effective senolytic. With the help of this extract, the research team tried to extend the life span and health span of mice.Scientists Managed to Reverse Aging in Mice with Grape Seed Extract

Aiming to test the effects of PCC1 on aging, the researchers prepared three experiments with mice. In the first experiment, they exposed mice to a sub-lethal dose of radiation to induce cellular senescence.

After this procedure, one group of mice received PCC1, while another group received the vehicle that carried the PCC1. The researchers found that after the mice underwent irradiation, they developed abnormal body features, including significant amounts of gray hair.

The mice that received treatment with PCC1 significantly reversed these features and also had fewer senescent cells as well as fewer biomarkers associated with senescent cells.

Poor Sleep Linked to Feeling Older, Which Can Affect Health

In a new study from the University of Exeter, researchers found that poor sleep in people over 50s is associated with more negative perceptions of aging, which in its turn can affect physical, mental, and cognitive health.Poor Sleep Linked to Feeling Older, Which Can Affect Health

For their study, a team of researchers surveyed 4,482 people aged 50 and older participating in the PROTECT study, an innovative online study in which participants take regular cognitive tests and complete lifestyle questionnaires.

Professor Clive Ballard, of the University of Exeter, says: “This research is an important part of the growing body of evidence about the crucial role of sleep in healthy aging. We now need more people to sign up to PROTECT, to help us understand this further. We’ve got some exciting trials ahead on how to optimize sleep in some particularly vulnerable groups, such as people with dementia in care homes.”

Exposure to Tobacco Smoke in Early Life Linked to Faster Biological Aging

According to the conclusions of an analysis led by the Barcelona Institute for Global Health (ISGlobal), individuals who were exposed to tobacco smoke in the womb and in early childhood are biologically aging at a faster pace.Exposure to Tobacco Smoke in Early Life Linked to Faster Biological Aging

For the study, a team of researchers investigated for the first time the association between the early-life exposome (83 prenatal exposures and 103 in early childhood) and the epigenetic age of 1,173 children between 6 and 11 years of age from the Human Early Life Exposome (HELIX) project, based on six birth cohorts in six European countries, including Spain, and coordinated by ISGlobal researcher Martine Vrijheid.

Mariona Bustamante, ISGlobal researcher and one of the authors of the study, says: “The positive association between epigenetic age acceleration and exposure to tobacco smoke during pregnancy and early childhood go in line with previous results obtained in the adult population.”

Study: Red Blood Cells May Ward Off Effects of Aging

A new study in mice, conducted by researchers from the University of Texas McGovern Medical School in Houston, U.S., finds that adenosine receptor ADORA2B, promoting the release of oxygen by hemoglobin, also seems to stave off some effects of aging by increasing oxygen supply to tissues. Theoretically, a drug that increases activity in this pathway will be able to help combat age-related declines.Study Red Blood Cells May Ward Off Effects of Aging

For their research, the scientists studied mice genetically engineered to lack ADORA2B in the membranes of their red blood cells. These rodents appeared to age at a younger age than it happened to normal mice. They also experienced steeper declines in their spatial learning, memory, and hearing abilities.

Lead researcher Dr. Yang Xia says: “Our findings reveal that the red blood cell ADORA2B signaling cascade combats the early onset of age-related decline in cognition, memory, and hearing by promoting oxygen delivery in mice and immediately highlight multiple new rejuvenating targets.”

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