Researchers from the Toulouse Institute for Infectious and Inflammatory Disease (Infinity) in France tested a prototype asthma vaccine in animals, and now intend to conduct a clinical trial in human patients hoping to get a safe, cost-effective, and long-term way to protect people from allergic asthma attacks.
While dupilumab, a monoclonal antibody, which effectively relieves the symptoms and improves lung function in cases of severe asthma due to blocking signaling from interleukin-4 (IL-4) and interleukin-13 (IL-13), two cytokine molecules that play a role in immune response, is expensive and require ongoing injection, whereas a vaccine achieving the same effect could provide cost-effective therapeutic effects in the long term.
The researchers write in their paper: “Conjugate vaccines called kinoids can elicit an endogenous, long-lasting neutralizing antibody response against a given cytokine, and could be a favorable alternative to therapeutic mAb administration.”
A study, recently published in ERJ Open Research, suggests that those teenagers who go to bed and wake up later are at higher risk to suffer from asthma and allergies than their peers who go to sleep and wake up earlier.
The research included 1,684 adolescents from West Bengal, India, 13 or 14 years old, who took part in the Prevalence and Risk Factors of Asthma and Allergy-Related Diseases among Adolescents (PERFORMANCE) study.
Study participants were asked about any wheezing, asthma, or symptoms of allergic rhinitis, such as a runny nose and sneezing. They also had to answer a series of questions to aimed to find whether they were ‘evening types’, ‘morning types’, or in between.
Lead study author Dr. Subhabrata Moitra from the division of pulmonary medicine at the University of Alberta, Canada, says: “Our results suggest there’s a link between preferred sleep time and asthma and allergies in teenagers. We can’t be certain that staying up late is causing asthma, but we know that the sleep hormone melatonin is often out of sync in late-sleepers and that could, in turn, be influencing teenagers’ allergic response.”
A new article, published in Annals of Allergy, Asthma and Immunology, says that insufficient sleep and sometimes excessive sleep may have a negative impact on adults with asthma, namely cause asthma more attacks.
In the study, described in the article, 1,389 adults whose age was above 20 years took part and said that they had asthma. Of all the participants, 25.9% slept 5 hours or less, 65.9% slept 6–8 hours, and 8.2% slept 9 and more hours.
People who slept less were more likely to have an asthma attack, dry cough, and an overnight hospitalization during the past year compared to those who had normal. At the same time, people who didn’t sleep enough had worse quality of life.
Allergist Gailen D. Marshall, MD, PhD, ACAAI member and Editor-in-Chief of Annals comments: “This study adds solid evidence to the practice of asthma patients discussing sleep issues with their allergist to help determine if they need to change their asthma plan to achieve adequate sleep as a component of overall good asthma management. It also warns that consequences can be expected when sleep patterns are chronically inadequate.”
A new study from the University of Bonn, Germany, suggests that a special diet, called ketogenic, may help people cope with asthma.
For the study, a team of scientists fed a group of mice with a so-called ketogenic diet, a low-carb and high-fat diet. After a certain period of time, the researchers registered reduced inflammation in the respiratory tract.
Prof. Dr. Christoph Wilhelm from the Institute for Clinical Chemistry and Clinical Pharmacology, who is a member of the Cluster of Excellence ImmunoSensation at the University of Bonn, explains: “We are therefore trying to determine which components of the dietary change are responsible for the effect. Maybe this will open the door to the development of new drugs.”
According to a new study, performed by the French scientists, people who eat a lot of fruit and vegetables have up to 30% less risk to experience the severe symptoms of asthma.
For their research, a team of scientists studied approximately 35,000 people comparing their diets and the symptoms of their asthma. The analysis of the received data showed that men who eat a more healthy diet tend to have a 30% lower risk to experience the symptoms of asthma. At the same time, women’s risk was 20% lower.
Lead researcher of the study Dr. Roland Andrianasolo says: “Our results strongly encourage the promotion of healthy diets for preventing asthma symptoms and managing the disease.”
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