Study: Abelacimab Can Be Effective in Blood Clot Treatment

Recent research, conducted by an international team of researchers and led by Jeffrey Weitz from McMaster University, finds that abelacimab could be more effective in blood clot treatment compared to other medications.Study Abelacimab Can Be Effective in Blood Clot Treatment

A team of researchers compared abelacimab with enoxaparin as a control drug in 412 patients undergoing knee replacement surgery. Scientists found that one abelacimab injection prevents forming of blood clots for up to 1 month after surgery, decreasing the risk by approximately 80% compared with enoxaparin without increasing the risk of bleeding.

Lead researcher Jeffrey Weitz, a hematologist and a professor of medicine and of biochemistry and biomedical sciences at McMaster’s Michael G. DeGroote School of Medicine, says: “This success of abelacimab in this study provides the foundation for its use for prevention of stroke in patients with atrial fibrillation and for treatment of deep-vein thrombosis and pulmonary embolism, clots in the veins of the leg and clots in the lung, in patients with cancer.”

COVID-19 May Result in Production of Clot-causing Autoantibodies

According to new research, led by a team of scientists from the University of Michigan, USA, COVID-19 may trigger the production of clot-causing autoantibodies and this may explain the high rate of blood clots in patients diagnosed with the disease.COVID-19 May Result in Production of Clot-causing Autoantibodies

The researchers found that more than half of the samples taken from the patients contained antiphospholipid (aPL) autoantibodies, using the threshold recommended by the test’s manufacturer. They also found evidence that the antibodies could cause blood clots in COVID-19 patients.

Co-author Dr. Yogendra Kanthi, a cardiologist and specialist in vascular medicine at the University of Michigan comments the study: “Antibodies from patients with active COVID-19 infection created a striking amount of clotting in animals — some of the worst clottings we’ve ever seen.”

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