Breast Cancer Drug May Prevent Growth of Brain Tumor

In a new study, a team of scientists from Northwestern University in Evanston, U.S, tested the breast cancer drug abemaciclib in a few patients and discovered their symptoms improved and the brain tumor size reduced.Breast Cancer Drug May Prevent Growth of Brain Tumor

For their study, the researchers used genomic data from 565 tumors from two cohorts of patients who had been followed up for 5–6 years and profiled the DNA methylation of the cancer genomes. After this, they analyzed this alongside the presence of DNA repeats at certain points in the genome and also looked at the RNA present in the tumors to determine which genes had and hadn’t been expressed.

Then, the researchers then tested the drug abemaciclib, a cancer drug used to treat breast cancer, on tumor cells in cell lines, organoids, and xenografts in mice. The experiment results showed that the drug could be used to treat individuals with either immune-enriched tumors or hypermitotic tumors.

Metabolic Memory Plays a Significant Role in Breast Cancer Recurrence

A group of scientists from Germany, Norway, and Great Britain identified molecular targets for therapies that could prevent breast cancer recurrence, having analyzed tumor cells that proved resistant to the original treatment.Metabolic Memory Plays a Significant Role in Breast Cancer Recurrence

The researchers analyzed methylation changes in cells that survive initial treatment, responsible for what is known as Minimal Residual Disease (MRD). MRD can proliferate after a considerable dormancy phase and cause an incurable relapse of cancer.

The most important what the scientists found was that the resistant cells demonstrated very similar metabolic behavior and methylation patterns to cells of the original tumor, but not to normal cells. Nonetheless, they did not have other characteristics of the original tumor cells, such as high proliferation propensity and the presence of oncogenic signaling.

That is why the team concluded that MRD cells carry some form of “metabolic and epigenetic memory” of the tumor state. To confirm the received result, the researchers used transcriptomic data from patients after they had received neoadjuvant therapy, which is usually a form of chemotherapy to shrink the tumor prior to surgical excision.

Weight Gain Linked to Lower Risk of Breast Cancer before Menopause

A new study, performed by scientists from The Institute of Cancer Research, London, finds that weight gain may reduce the risk of developing breast cancer before menopause.Weight Gain Linked to Lower Risk of Breast Cancer before Menopause

For the study, a team of researchers analyzed data from 628,463 women from numerous separate studies from all around the globe. They divided women into 6 age groups, collected information concerning their weight at a minimum two different ages, and followed them for 10.1 years, on average.

Dr. Minouk Schoemaker, a lead author of the study, says: “The link between a higher body mass index and a lower breast cancer risk before menopause has puzzled researchers for a while now. In our large-scale international study, we were able to tease out the effects in more detail than ever before.”

Weight Loss after 50 Linked to Lower Breast Cancer Risk

According to a large study, conducted recently by the American Cancer Society, women who lost weight after the age of 50 years and managed to keep it off have a lower risk of developing breast cancer than women whose weight didn’t change.Weight Loss after 50 Linked to Lower Breast Cancer Risk

To examine the link between weight loss and lower risk of the condition, a team of researchers used data from the Pooling Project of Prospective Studies of Diet and Cancer 9DCPP). They analyzed data from more than 180,000 women aged 50 and over from 10 prospective studies.

The analysis showed that women who lost 2 to 4.5 kg (about 4.4 to 10 lbs) had a 13% lower risk; women who lost from 4.5 to 9 kg (10-20 lbs) had a 16% lower risk, and women who lost 9 kg or more (20+ lbs) had a 26% lower risk.

Choosing Chicken Instead of Pork May Cut Breast Cancer Risk

A new study suggests that eating chicken instead of beef, lamb, or pork may decrease a woman’s risk of developing breast cancer by 28%.Choosing Chicken Instead of Pork May Cut Breast Cancer Risk

For the study, the US National Cancer Institute analyzed the diets of more than 42,000 women and tracked their health and wellbeing for 8 years. The analysis showed that those women who ate red meat the most were almost 25% more likely to develop the condition than those who ate the least.

Study author Dr Dale Sandler says: “Red meat has been identified as a probable carcinogen. Our study adds further evidence red meat consumption may be associated with increased risk of breast cancer whereas poultry was associated with decreased risk.”

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