A team of researchers analyzed data from 101,257 French adults whose median age was 42 from the NutriNet-Santé study to check the association between the consumption of sugary drinks and various forms of cancer.
The drinks included sugar-sweetened beverages such as soft drinks, syrups, fruit drinks, 100% fruit juices without added sugar, milk-based sugary drinks, sports drinks, and energy drinks.
Having analyzed the available data, the researchers concluded that a daily increase of 100 ml in the intake of this type of drinks associated with the higher risk of developing cancer by 18%, and the breast cancer risk raise by 22%.
To check their new technique, the scientists applied the engineered strain to mice with cancer, and the delivered therapy led not only to complete tumor regression of lymphoma, but also significant control of distant, uninjected tumor lesions.
Tal Danino, assistant professor of biomedical engineering, comments: “Seeing untreated tumors respond alongside treatment of primary lesions was an unexpected discovery. It is the first demonstration following a bacterial cancer therapy of what is termed an ‘abscopal’ effect. This means that we’ll be able to engineer bacteria to prime tumors locally, and then stimulate the immune system to seek out tumors and metastases that are too small to be detected with imaging or other approaches.”
A new study, published in Science, shows that targeting the gene, known as WWP1, with the compound in broccoli suppressed the tumor growth in cancer-prone laboratory animals.
Study author Pier Paolo Pandolfi, MD, PhD, Director of the Cancer Center and Cancer Research Institute at Beth Israel Deaconess Medical Center, comments: “We found a new important player that drives a pathway critical to the development of cancer, an enzyme that can be inhibited with a natural compound found in broccoli and other cruciferous vegetables. This pathway emerges not only as a regulator for tumor growth control but also as an Achilles’ heel we can target with therapeutic options.”
Still, to get the right amount of this ingredient is quite challenging – one will have to eat approximately 6 pounds of the uncooked vegetable. So now the scientists are working at the task to apply this knowledge as an appropriate medication.
A recent international study, published in Nature Communications, finds that gut microbiome can boost the immune system’s ability to fight cancer.
During the study, a team of researchers identified 11 strains of gut bacteria which helped the immune system to slow down the growth of melanoma tumors in mice. The scientists highlighted a signaling pathway called unfolded protein response (UPR) as a major link between the gut bacteria and the fighting ability of the immune system.
Senior study author Ze’ev Ronai, a professor at Sanford Burnham Prebys, says: “These results […] identify a collection of bacterial strains that could turn on antitumor immunity and biomarkers that could be used to stratify people with melanoma for treatment with select checkpoint inhibitors.”
Researchers from the University of Kansas (KU) in Lawrence and the KU Cancer Center and KU Medical Center in Kansas City, both USA, developed an ultrasensitive device that can detect cancer in just a drop of blood.
The device is called a 3-D nanopatterned microfluidic chip. It can detect cancer markers in the smallest quantity of whole blood or in plasma by filtering for exosomes, tiny vesicles that some eukaryotic cell produce. Cancer exosomes contain biological information about tumor growth and spread.
Lead author Yong Zeng, an associate professor of chemistry at KU, comments: “Almost all mammalian cells release exosomes, so the application is not just limited to ovarian cancer or any one type of cancer. We’re working with people to look at neurodegenerative diseases, breast, and colorectal cancer, for example.”