A new study finds that in the process of digestion of such green vegetables as kale, cabbage, and broccoli a protein, known as aryl hydrocarbon receptor (AhR), is activated that reduces gut inflammation and prevents the colon form of cancer.
For the study, a team of researchers analyzed genetically modified mice that were not able to produce or activate AhR in their intestines. These rodents developed gut inflammation that led to bowel cancer, while those animals who were fed with green vegetables didn’t develop gut inflammation.
Lead author of the study Dr. Amina Metidji says: “Interestingly when mice whose cancer was already developing were switched to the [green vegetable]-enriched diet, they ended up with significantly fewer tumors which were also more benign. It’s not just fiber in vegetables that reduces the risk of bowel cancer.”
Raised sensitivity to bitter tastes might be an indicator of higher risk of cancer in women, according to a new research, conducted by scientists at the College of Agriculture Sciences of Pennsylvania State University in State College (US) in association with a team of researchers from Leeds University (UK).
For the study, the researchers collected data via the UK Women’s Cohort Study, founded in 1995 by scientists at Leeds University. The researchers split women into 3 groups according to their sensitivity to bitterness: “super-tasters”, “tasters,” and “non-tasters.” The analysis of the received data showed that “super-tasters” and “tasters” were at higher risk of cancer than those who couldn’t taste bitterness.
Lead researcher Joshua Lambert explains: “The difference in cancer incidence between the women with the highest bitter-taste sensitivity and those with the lowest was striking. Super-tasters had about a 58 percent higher risk of cancer incidence and the tasters had about a 40 percent higher risk of developing cancer, compared to women who were classified as non-tasters.”
Cancer has a double-edged strategy to get past the macrophages, the largest immune cells in the body. However, the scientists from the Brigham and Women’s Hospital in Boston, US, might have found a way to outwit cancer cells.
A team of researchers developed a “supramolecule”, a chemical structure made of smaller molecules bond together similar to LEGO pieces. This molecule is able to block cancer cells’ specific signals. The researchers tested the supramolecule on mouse models with aggressive breast and skin cancer. The mice treated with the created molecule demonstrated complete inhibition of tumor growth and of formation of metastatic nodules.
Lead author of the study Ashish Kulkarni, an assistant professor in the Department of Chemical Engineering at University of Massachusetts, says: “Clinicians are increasingly realizing that one drug or one-size-fits-all approach is not enough when combating cancer and that a combination immunotherapy, such as blocking two distinct targets in the same immune cell, is the future of immunology. Our approach capitalizes on this concept.”
A new study from Brazil demonstrates how resveratrol, the chemical compound in grapes and red wine, may have anticancer properties and prevent cancer, especially breast cancer.
A team of researchers carried out immunofluorescence colocalization assays to test the efficacy of resveratrol on breast cancer cell lines that had different p53 mutations and on breast cancer cells with normal p53.
The tests showed that resveratrol inhibited the aggregation of p53 in both human breast cancer cells and in the rodents’ tumors.
The authors of the study conclude: “This study provides evidence that resveratrol directly modulates p53 and enhances our understanding of the mechanisms involved in p53 aggregation as a therapeutic strategy for cancer treatment. Our data indicate that resveratrol is a highly promising lead compound targeted against mutant p53 aggregation.”
A team of researchers from Massachusetts Institute of Technology (MIT) has developed a type of nanoparticle that can be loaded with drugs and move across the patient’s body to the brain tissue and kill brain tumors.
At the present moment, the experiments were made using mouse model but in case of success, the research could provide an effective treatment for tumors that generally claim a patient’s life within only 15 months after diagnosis.
Lead author Fred Lam from MIT’s Koch Institute says: “Our goal was to have something that could be easily translatable, by using simple, already approved synthetic components in the liposome. This was really a proof-of-concept study [showing] that we can deliver novel combination therapies using a targeted nanoparticle system across the blood-brain barrier.”