A new study, conducted by researchers from the UT Southwestern Medical Center, finds that a high-sugar diet can damage the gut and increase the risk of developing colitis, a type of inflammatory bowel disease.
To examine the sugar effect on the gut, a team of scientists fed mice with a solution of water with a 10% concentration of sugars such as glucose, fructose, and sucrose for 7 days. They found that mice that received sugar developed more severe sugar of colitis.
The researchers write in their paper: “Due to the erosion of the mucus layer, gut bacteria were in close proximity with the epithelial layer of the large intestine in glucose-treated mice. Breaching of the epithelial barrier is the key initiating event of intestinal inflammation.”
A new study, conducted by researchers from the University of Connecticut, US, suggests that walnuts may protect against ulcerative colitis thanks to the high content of natural compounds and phytochemicals.
The effect of walnuts was checked using a mouse model where the colonic mucosal injury was induced by the ulcerogenic agent dextran sodium sulfate. The daily dose of walnuts in the study was equivalent of 20 to 25 walnuts in a human which was 14% of the studied diet.
Dr. Daniel Rosenberg, professor of medicine, and Masako Nakanishi, post-doctoral fellow, at the Center for Molecular Oncology at UConn Health, who led the study, says: “We are continuing our work to understand whether those metabolic changes are part of the protection. We are not suggesting that people with ulcerative colitis be maintained on a large walnut diet between active flares. But, we are hoping that we’ll be able to determine the active compounds — nutrients, phytochemicals — in walnuts that cause protection.”
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