A new study, carried out by a team of researchers Harvard T.H. Chan School of Public Health in Boston, U.S., has found a link between a higher total intake of vitamin D and a lower risk of colon cancer in adults, younger than 50 years.
For the study, the researchers analyzed the diets, lifestyle, and medical history of 116,429 female nurses aged 25–42 years old, who participated in the Nurses’ Health Study II (NHS II), which started in 1989.
Having adjusted known risks, including smoking, drinking alcohol, red meat consumption, and a sedentary lifestyle, the scientists found that total vitamin D intake was significantly associated with a reduced risk of early-onset colorectal cancer.
The lead author of the study, Dr. Ng, comments: “Our findings suggest that as little as 300 [international units or IU per day] of vitamin D (approximately 3 glasses of milk per day) may be associated with a 50% decreased risk of young-onset colorectal cancer.”
Recent research, presented at the European Society for Medical Oncology World Congress on Gastrointestinal Cancer 2021, suggests that people, especially those who are 50 years and over, may have a higher risk of colorectal cancer due to overuse of antibiotics.
For the study, a team of scientists analyzed data of a total of 7,903 individuals with colorectal cancer, comparing them with the data of 30,418 individuals without the condition. Of the study participants diagnosed with colorectal cancers, 445 were under the age of 50.
The analysis showed that there is a link between antibiotic use and a higher risk of colorectal cancer. The researchers also noted that individuals with later-onset colorectal cancer had an associated risk of 9%. The association was significantly higher in those with early-onset colorectal cancer, with an almost 50% increased risk.
A new study, completed by researchers from Vanderbilt University Medical Center, suggests that people with a higher genetic risk of developing colorectal cancer could more successfully prevent the disease by applying lifestyle changes compared to those with lower genetic risk.
For the study, a team of researchers analyzed data from participants in the UK Biobank. Having performed the analysis, the scientists concluded that leading a healthy lifestyle was associated with an approximately 40% reduction in colorectal cancer risk in people with a higher polygenetic risk score. However, the percentage was significantly lower, about 25%, in people at low genetic risk for this cancer.
Wei Zheng, MD, PhD, MPH, Anne Potter Wilson Professor of Medicine and associate director for Population Sciences Research at Vanderbilt-Ingram Cancer Center (VICC), believe that results from this study could be useful to design personalized prevention strategies for colorectal cancer prevention.
A study, recently published in the British Journal of Cancer, suggests that lifetime exercise is associated with a significantly lower risk of developing colon polyps in senior age.
The study includes analysis of data from 28,250 US nurses from the Nurses’ Health Study II which took place from the late 1980s till years 2011. The health information included all illnesses and habits, medicines taken, and other conditions.
The analysis of the data showed that people who were physically active between 12 and 22 were 7% less likely to develop polyps; those who exercised during adulthood, between 23 and 64, had 9% lower risk, and those who were active in both age intervals had 24% lower risk of developing polyps.
One of the study authors Leandro Rezende says: “Whether it’s during adolescence or adulthood, the more physical activity we get, the lower the risk of developing adenoma in adulthood becomes.”
According to new research, published in the journal Gut, the use of antibiotics in pills and capsules is associated with the higher risk of colon cancer but lower risk of rectal cancer at the same time. Researchers say this risk depends on the type and class of antibiotics prescribed.
The researchers drew on data submitted to the nationally representative Clinical Practice Research Datalink (CPRD) between 1989 and 2012 which included the records of approximately 11.3 mln people from 674 general practices which is about 7% of the population of the United Kingdom.
The authors of the study conclude in their paper: “Whether antibiotic exposure is causal or contributory to colon cancer risk, our results highlight the importance of judicious antibiotic use by clinicians.”
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