Scientists from Hawaii found that smokers with particular genetic markers might have higher nicotine metabolism, increasing the quantity of smoke they can inhale and the risk of lung cancer correspondingly. They identified differences in the CYP2A6 gene that are linked to a high rate of nicotine metabolism.
The higher nicotine metabolism is, the more cigarettes a person can smoke and inhale more nicotine per cigarette.
Dr. Loїc Le Marchand, a professor in the UH Cancer Center’s Epidemiology program, says: “Smokers with the genetic markers we discovered, smoke more extensively in order to keep their nicotine levels high and achieve the desired effects of nicotine in the brain.”
He also believes that this finding can help identify smokers who are at an increased risk of lung cancer.
More details here.