A new study from Denmark shows that such widespread painkiller as ibuprofen can have a significant negative effect on male fertility affecting testicular health, altering hormone production and inducing compensated hypogonadism.
For the research, the scientists recruited 31 men aged between 18 and 35 half of whom received a moderate dose (600 mg, or three tablets) of the drug daily during six weeks. The other group received placebo. Within 2 weeks, the men who were taking ibuprofen on a daily basis demonstrated an increase in luteinizing hormones.
The team writes in their paper: “It is also of concern that men with compensated hypogonadism may eventually progress to overt primary hypogonadism, which is characterized by low-circulating testosterone and prevalent symptoms including reduced libido, reduced muscle mass and strength, and depressed mood and fatigue.”
A recent study, published in The BMJ, suggests that people who commonly take high doses of common non-steroidal anti-inflammatory painkillers, or NSAIDs, such as ibuprofen and naproxen, could be at a higher risk of a heart attack.
An international team of researchers with Michele Bally of the University of Montreal Hospital Research Center as a leader of the study analyzed health care data of 446,763 people from Canada, Finland, and the United Kingdom, among whom 61,460 had a heart attack.
High doses were considered as following: > 200 mg for Celecoxib (Celebrex), > 100 mg for Diclofenac (Voltaren, Cambia, Solaraze), > 1200 mg for Ibuprofen (Advil), > 750 mg for Naproxen (Midol, Aleve, Naprelan).
Deepak Bhatt, M.D., executive director of an interventional cardiovascular program at Brigham and Women’s hospital, says: “The bottom line [of the study] is, don’t treat these drugs like candy just because they’re sold over the counter said. Treat them like any medications. Only use them if you really need to, lowest dose possible, for least amount of time.”
A new study says that common painkillers may increase the risk of heart failure. Such non-steroidal anti-inflammatory drugs, as ibuprofen, naproxen, and diclofenac, are widely used for treatment of pain and inflammation.
For their study, the researcher have analysed data for the 10 million users from the United Kingdom, the Netherlands, Italy and Germany, and compared them with data of people who have never taken this kind of drugs.
The researchers from University of Milano-Bicocca, Italy, found taking NSAIDs increased the risk of being taken to hospital with heart failure by 19%. Since most people in the study were seniors – and those on NSAIDs were, in general, in poorer health – UK health experts suggested the findings had very little relevance for most patients under 65, but may be a concern for elderly patients.
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